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| 23.04.2022 | 13:00 | Arminia Bielefeld | - | Schalke | 0:3 (0:0) | |
| 13:00 | MSV Duisburg | - | Colonia | 2:1 (1:0) | ||
| 13:00 | Fortuna Köln | - | Fortuna Düsseldorf | 2:3 (2:1) | ||
| 13:00 | SC Paderborn 07 | - | Alemannia Aachen | 3:1 (1:0) | ||
| 13:00 | Rot-Weiß Oberhausen | - | Bayer Leverkusen | 3:1 (1:1) | ||
| 13:00 | Rot-Weiss Essen | - | Wuppertaler SV | 2:1 (1:0) | ||
| 13:00 | Preußen Münster | - | Borussia Dortmund | 1:5 (0:2) | ||
| 13:00 | VfL Bochum | - | Viktoria Köln | 4:0 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Borussia Dortmund | 15 | 13 | 2 | 0 | 53:7 | 46 | 41 |
| 2 |
|
Schalke | 16 | 10 | 3 | 3 | 37:14 | 23 | 33 |
| 3 |
|
Bayer Leverkusen | 15 | 9 | 4 | 2 | 31:13 | 18 | 31 |
| 4 |
|
VfL Bochum | 15 | 8 | 5 | 2 | 22:9 | 13 | 29 |
| 5 |
|
Rot-Weiss Essen | 15 | 8 | 4 | 3 | 25:18 | 7 | 28 |
| 6 |
|
Colonia | 15 | 7 | 4 | 4 | 34:16 | 18 | 25 |
| 7 |
|
Preußen Münster | 15 | 8 | 1 | 6 | 33:25 | 8 | 25 |
| 8 |
|
MSV Duisburg | 15 | 6 | 5 | 4 | 24:14 | 10 | 23 |
| 9 |
|
Viktoria Köln | 15 | 6 | 3 | 6 | 25:26 | -1 | 21 |
| 10 |
|
Rot-Weiß Oberhausen | 15 | 5 | 4 | 6 | 23:27 | -4 | 19 |
| 11 |
|
SC Paderborn 07 | 15 | 5 | 3 | 7 | 25:22 | 3 | 18 |
| 12 |
|
Bor. Mönchengladbach | 15 | 4 | 6 | 5 | 23:22 | 1 | 18 |
| 13 |
|
Fortuna Düsseldorf | 15 | 5 | 2 | 8 | 19:36 | -17 | 17 |
| 14 |
|
Wuppertaler SV | 15 | 4 | 2 | 9 | 10:40 | -30 | 14 |
| 15 |
|
Arminia Bielefeld | 15 | 2 | 3 | 10 | 9:27 | -18 | 9 |
| 16 |
|
Fortuna Köln | 15 | 2 | 1 | 12 | 14:36 | -22 | 7 |
| 17 |
|
Alemannia Aachen | 15 | 0 | 0 | 15 | 5:60 | -55 | 0 |
| Playoff | |
| Descenso |
