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| 15.07.2022 | 02:10 | Villa Dálmine | - | Nueva Chicago | 4:3 (3:3) | |
| 20:00 | Deportivo Riestra | - | Quilmes | 1:1 (0:1) | ||
| 16.07.2022 | 02:10 | All Boys | - | Ferro Carril Oeste | 3:1 (2:1) | |
| 19:10 | Atlanta | - | Tristan Suárez | 1:0 (0:0) | ||
| 20:00 | Temperley | - | Deportivo Madryn | 1:1 (0:1) | ||
| 20:00 | Flandria | - | Estudiantes de Río Cuarto | 0:1 (0:1) | ||
| 20:30 | San Martín de San Juan | - | Agropecuario Argentino | 3:0 (1:0) | ||
| 20:30 | Gimnasia de Mendoza | - | Mitre de SdE | 3:0 (0:0) | ||
| 23:10 | Estudiantes de Caseros | - | San Martín de Tucumán | 0:0 (0:0) | ||
| 17.07.2022 | 20:00 | San Telmo | - | Sacachispas | 0:0 (0:0) | |
| 20:05 | Guillermo Brown | - | Chacarita Juniors | 0:0 (0:0) | ||
| 20:30 | Gimnasia de Jujuy | - | Alvarado | 3:2 (1:1) | ||
| 21:00 | Atlético Rafaela | - | Brown de Adrogué | 1:0 (0:0) | ||
| 21:00 | Chaco For Ever | - | Instituto de Córdoba | 1:2 (1:1) | ||
| 22:10 | Belgrano | - | Deportivo Maipú | 1:0 (0:0) | ||
| 22:40 | Almirante Brown | - | Almagro | 0:0 (0:0) | ||
| 18.07.2022 | 23:05 | Güemes de SdE | - | Independiente Rivadavia | 0:0 (0:0) | |
| 19.07.2022 | 02:30 | Ramón Santamarina | - | Defensores de Belgrano | 1:1 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano | 23 | 17 | 4 | 2 | 29:12 | 17 | 55 |
| 2 |
|
San Martín de Tucumán | 23 | 12 | 9 | 2 | 30:15 | 15 | 45 |
| 3 |
|
Instituto de Córdoba | 23 | 12 | 8 | 3 | 29:16 | 13 | 44 |
| 4 |
|
All Boys | 23 | 10 | 12 | 1 | 35:18 | 17 | 42 |
| 5 |
|
Gimnasia de Mendoza | 23 | 10 | 9 | 4 | 28:12 | 16 | 39 |
| 6 |
|
Estudiantes de Río Cuarto | 24 | 10 | 9 | 5 | 28:23 | 5 | 39 |
| 7 |
|
San Martín de San Juan | 24 | 11 | 5 | 8 | 35:23 | 12 | 38 |
| 8 |
|
Brown de Adrogué | 23 | 10 | 8 | 5 | 29:21 | 8 | 38 |
| 9 |
|
Almagro | 24 | 10 | 6 | 8 | 21:22 | -1 | 36 |
| 10 |
|
Deportivo Madryn | 24 | 8 | 11 | 5 | 33:25 | 8 | 35 |
| 11 |
|
Independiente Rivadavia | 23 | 9 | 7 | 7 | 30:23 | 7 | 34 |
| 12 |
|
Chaco For Ever | 24 | 7 | 12 | 5 | 26:20 | 6 | 33 |
| 13 |
|
Deportivo Riestra | 23 | 7 | 12 | 4 | 22:18 | 4 | 33 |
| 14 |
|
Chacarita Juniors | 23 | 8 | 8 | 7 | 33:29 | 4 | 32 |
| 15 |
|
Defensores de Belgrano | 23 | 7 | 11 | 5 | 25:21 | 4 | 32 |
| 16 |
|
Estudiantes de Caseros | 24 | 8 | 8 | 8 | 20:21 | -1 | 32 |
| 17 |
|
Guillermo Brown | 24 | 9 | 5 | 10 | 20:23 | -3 | 32 |
| 18 |
|
Deportivo Maipú | 24 | 6 | 13 | 5 | 24:22 | 2 | 31 |
| 19 |
|
Güemes de SdE | 23 | 7 | 8 | 8 | 19:18 | 1 | 29 |
| 20 |
|
Agropecuario Argentino | 23 | 6 | 11 | 6 | 22:22 | 0 | 29 |
| 21 |
|
Gimnasia de Jujuy | 23 | 7 | 8 | 8 | 25:29 | -4 | 29 |
| 22 |
|
Quilmes | 23 | 6 | 9 | 8 | 28:30 | -2 | 27 |
| 23 |
|
Ferro Carril Oeste | 23 | 6 | 9 | 8 | 19:25 | -6 | 27 |
| 24 |
|
Almirante Brown | 23 | 5 | 11 | 7 | 24:28 | -4 | 26 |
| 25 |
|
Deportivo Morón | 23 | 4 | 13 | 6 | 14:14 | 0 | 25 |
| 26 |
|
Mitre de SdE | 23 | 6 | 7 | 10 | 23:27 | -4 | 25 |
| 27 |
|
Atlanta | 24 | 5 | 10 | 9 | 19:23 | -4 | 25 |
| 28 |
|
Alvarado | 24 | 6 | 7 | 11 | 23:38 | -15 | 25 |
| 29 |
|
Temperley | 23 | 5 | 9 | 9 | 20:28 | -8 | 24 |
| 30 |
|
Nueva Chicago | 24 | 5 | 9 | 10 | 24:33 | -9 | 24 |
| 31 |
|
Atlético Rafaela | 24 | 4 | 11 | 9 | 22:27 | -5 | 23 |
| 32 |
|
San Telmo | 23 | 5 | 8 | 10 | 23:37 | -14 | 23 |
| 33 |
|
Sacachispas | 23 | 3 | 13 | 7 | 17:25 | -8 | 22 |
| 34 |
|
Tristan Suárez | 23 | 4 | 8 | 11 | 24:30 | -6 | 20 |
| 35 |
|
Flandria | 23 | 4 | 8 | 11 | 23:31 | -8 | 20 |
| 36 |
|
Villa Dálmine | 23 | 3 | 11 | 9 | 27:39 | -12 | 20 |
| 37 |
|
Ramón Santamarina | 24 | 2 | 9 | 13 | 15:40 | -25 | 15 |
| Ascenso | |
| Playoff | |
| Playoff | |
| Descenso |
