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| 19.08.2022 | 20:30 | Estudiantes de Caseros | - | Ramón Santamarina | 1:0 (0:0) | |
| 20.08.2022 | 02:10 | Belgrano | - | Instituto de Córdoba | 1:0 (1:0) | |
| 19:10 | Gimnasia de Mendoza | - | Defensores de Belgrano | 0:1 (0:0) | ||
| 20:00 | Deportivo Riestra | - | Agropecuario Argentino | 1:0 (1:0) | ||
| 20:00 | Flandria | - | Independiente Rivadavia | 0:1 (0:0) | ||
| 20:00 | Villa Dálmine | - | Sacachispas | 0:0 (0:0) | ||
| 20:45 | San Martín de San Juan | - | Guillermo Brown | 4:1 (3:1) | ||
| 23:10 | Temperley | - | Quilmes | 2:3 (1:0) | ||
| 21.08.2022 | 01:10 | All Boys | - | San Martín de Tucumán | 2:2 (1:0) | |
| 18:10 | Almirante Brown | - | Mitre de SdE | 2:0 (2:0) | ||
| 20:00 | Deportivo Madryn | - | Nueva Chicago | 1:0 (1:0) | ||
| 20:00 | Gimnasia de Jujuy | - | Ferro Carril Oeste | 0:1 (0:0) | ||
| 20:10 | Chaco For Ever | - | Chacarita Juniors | 2:0 (0:0) | ||
| 20:30 | Deportivo Morón | - | Deportivo Maipú | 1:0 (0:0) | ||
| 20:30 | San Telmo | - | Brown de Adrogué | 1:1 (0:1) | ||
| 21:30 | Estudiantes de Río Cuarto | - | Almagro | 1:0 (0:0) | ||
| 23.08.2022 | 00:00 | Atlanta | - | Atlético Rafaela | 0:0 (0:0) | |
| 02:00 | Güemes de SdE | - | Tristan Suárez | 0:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano | 29 | 18 | 7 | 4 | 33:19 | 14 | 61 |
| 2 |
|
San Martín de Tucumán | 29 | 13 | 13 | 3 | 34:18 | 16 | 52 |
| 3 |
|
Instituto de Córdoba | 29 | 14 | 10 | 5 | 35:21 | 14 | 52 |
| 4 |
|
All Boys | 29 | 12 | 14 | 3 | 40:24 | 16 | 50 |
| 5 |
|
Gimnasia de Mendoza | 29 | 12 | 12 | 5 | 31:13 | 18 | 48 |
| 6 |
|
Estudiantes de Río Cuarto | 29 | 12 | 12 | 5 | 33:26 | 7 | 48 |
| 7 |
|
Chaco For Ever | 30 | 11 | 14 | 5 | 32:21 | 11 | 47 |
| 8 |
|
Estudiantes de Caseros | 30 | 13 | 8 | 9 | 28:25 | 3 | 47 |
| 9 |
|
Independiente Rivadavia | 29 | 12 | 9 | 8 | 37:27 | 10 | 45 |
| 10 |
|
San Martín de San Juan | 30 | 13 | 6 | 11 | 43:34 | 9 | 45 |
| 11 |
|
Defensores de Belgrano | 29 | 11 | 12 | 6 | 31:22 | 9 | 45 |
| 12 |
|
Deportivo Riestra | 29 | 10 | 14 | 5 | 28:22 | 6 | 44 |
| 13 |
|
Almagro | 30 | 12 | 8 | 10 | 28:28 | 0 | 44 |
| 14 |
|
Deportivo Madryn | 29 | 9 | 14 | 6 | 37:29 | 8 | 41 |
| 15 |
|
Deportivo Maipú | 30 | 9 | 14 | 7 | 35:27 | 8 | 41 |
| 16 |
|
Deportivo Morón | 29 | 8 | 15 | 6 | 23:17 | 6 | 39 |
| 17 |
|
Brown de Adrogué | 29 | 10 | 9 | 10 | 34:31 | 3 | 39 |
| 18 |
|
Ferro Carril Oeste | 29 | 10 | 9 | 10 | 24:27 | -3 | 39 |
| 19 |
|
Guillermo Brown | 29 | 11 | 5 | 13 | 26:34 | -8 | 38 |
| 20 |
|
Chacarita Juniors | 29 | 9 | 10 | 10 | 39:37 | 2 | 37 |
| 21 |
|
Quilmes | 29 | 9 | 10 | 10 | 35:37 | -2 | 37 |
| 22 |
|
Almirante Brown | 29 | 8 | 12 | 9 | 32:34 | -2 | 36 |
|
Mitre de SdE | 29 | 9 | 9 | 11 | 32:34 | -2 | 36 | |
| 24 |
|
Agropecuario Argentino | 29 | 7 | 14 | 8 | 24:24 | 0 | 35 |
| 25 |
|
Güemes de SdE | 29 | 8 | 11 | 10 | 23:23 | 0 | 35 |
| 26 |
|
Gimnasia de Jujuy | 29 | 9 | 8 | 12 | 31:39 | -8 | 35 |
| 27 |
|
San Telmo | 29 | 7 | 11 | 11 | 27:40 | -13 | 32 |
| 28 |
|
Atlanta | 30 | 6 | 13 | 11 | 22:28 | -6 | 31 |
| 29 |
|
Temperley | 29 | 5 | 13 | 11 | 26:36 | -10 | 28 |
| 30 |
|
Villa Dálmine | 29 | 5 | 13 | 11 | 32:46 | -14 | 28 |
| 31 |
|
Alvarado | 29 | 6 | 10 | 13 | 26:43 | -17 | 28 |
| 32 |
|
Atlético Rafaela | 29 | 5 | 12 | 12 | 29:36 | -7 | 27 |
| 33 |
|
Nueva Chicago | 30 | 5 | 12 | 13 | 29:42 | -13 | 27 |
| 34 |
|
Tristan Suárez | 29 | 5 | 10 | 14 | 27:34 | -7 | 25 |
| 35 |
|
Flandria | 29 | 5 | 10 | 14 | 27:39 | -12 | 25 |
| 36 |
|
Sacachispas | 29 | 3 | 16 | 10 | 19:32 | -13 | 25 |
| 37 |
|
Ramón Santamarina | 29 | 5 | 9 | 15 | 21:44 | -23 | 24 |
| Ascenso | |
| Playoff | |
| Playoff | |
| Descenso |
