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| 17.03.2022 | 19:05 | Sacachispas | - | Independiente Rivadavia | 3:1 (1:0) | |
| 21:05 | Atlanta | - | Almirante Brown | 1:1 (0:1) | ||
| 18.03.2022 | 19:05 | Brown de Adrogué | - | Estudiantes de Río Cuarto | 1:1 (1:1) | |
| 20:00 | San Telmo | - | Deportivo Riestra | 0:0 (0:0) | ||
| 21:30 | San Martín de San Juan | - | Villa Dálmine | 4:0 (3:0) | ||
| 23:10 | Atlético Rafaela | - | Temperley | 1:0 (1:0) | ||
| 19.03.2022 | 00:00 | Agropecuario Argentino | - | Deportivo Maipú | 2:0 (1:0) | |
| 00:00 | Tristan Suárez | - | Nueva Chicago | 3:4 (1:0) | ||
| 01:10 | Instituto de Córdoba | - | Quilmes | 0:0 (0:0) | ||
| 19:30 | Defensores de Belgrano | - | Alvarado | 2:1 (1:1) | ||
| 20:00 | Estudiantes de Caseros | - | Gimnasia de Jujuy | 1:0 (0:0) | ||
| 20:00 | Chacarita Juniors | - | Deportivo Madryn | 0:2 (0:0) | ||
| 20:00 | Guillermo Brown | - | Deportivo Morón | 0:0 (0:0) | ||
| 21:00 | Gimnasia de Mendoza | - | Güemes de SdE | 1:1 (1:0) | ||
| 22:00 | San Martín de Tucumán | - | Almagro | 2:0 (1:0) | ||
| 22:30 | Chaco For Ever | - | Belgrano | 3:1 (2:0) | ||
| 23:30 | Mitre de SdE | - | Ferro Carril Oeste | 1:1 (0:0) | ||
| 20.03.2022 | 00:00 | Ramón Santamarina | - | Flandria | 1:1 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
San Martín de Tucumán | 6 | 4 | 1 | 1 | 9:5 | 4 | 13 |
| 2 |
|
Belgrano | 6 | 4 | 1 | 1 | 8:5 | 3 | 13 |
|
Guillermo Brown | 6 | 4 | 1 | 1 | 8:5 | 3 | 13 | |
| 4 |
|
Brown de Adrogué | 6 | 3 | 3 | 0 | 10:5 | 5 | 12 |
| 5 |
|
Deportivo Riestra | 6 | 3 | 3 | 0 | 5:1 | 4 | 12 |
| 6 |
|
Deportivo Madryn | 6 | 3 | 2 | 1 | 8:5 | 3 | 11 |
| 7 |
|
Almirante Brown | 6 | 3 | 2 | 1 | 10:8 | 2 | 11 |
| 8 |
|
Chaco For Ever | 6 | 2 | 4 | 0 | 8:5 | 3 | 10 |
| 9 |
|
Instituto de Córdoba | 6 | 2 | 4 | 0 | 5:3 | 2 | 10 |
| 10 |
|
Almagro | 6 | 3 | 1 | 2 | 6:6 | 0 | 10 |
| 11 |
|
All Boys | 5 | 2 | 3 | 0 | 6:4 | 2 | 9 |
| 12 |
|
Deportivo Maipú | 6 | 2 | 3 | 1 | 5:5 | 0 | 9 |
| 13 |
|
Quilmes | 5 | 2 | 2 | 1 | 6:4 | 2 | 8 |
| 14 |
|
Defensores de Belgrano | 6 | 2 | 2 | 2 | 7:7 | 0 | 8 |
|
Nueva Chicago | 6 | 2 | 2 | 2 | 7:7 | 0 | 8 | |
| 16 |
|
Independiente Rivadavia | 5 | 2 | 2 | 1 | 4:4 | 0 | 8 |
| 17 |
|
Gimnasia de Jujuy | 6 | 2 | 2 | 2 | 7:8 | -1 | 8 |
| 18 |
|
Chacarita Juniors | 6 | 2 | 2 | 2 | 7:9 | -2 | 8 |
| 19 |
|
Alvarado | 6 | 1 | 4 | 1 | 8:7 | 1 | 7 |
| 20 |
|
Sacachispas | 6 | 1 | 4 | 1 | 7:6 | 1 | 7 |
| 21 |
|
Atlético Rafaela | 6 | 2 | 1 | 3 | 6:5 | 1 | 7 |
|
San Martín de San Juan | 6 | 2 | 1 | 3 | 6:5 | 1 | 7 | |
| 23 |
|
Atlanta | 6 | 1 | 3 | 2 | 5:5 | 0 | 6 |
| 24 |
|
Estudiantes de Caseros | 6 | 1 | 3 | 2 | 5:6 | -1 | 6 |
| 25 |
|
San Telmo | 5 | 1 | 3 | 1 | 3:5 | -2 | 6 |
| 26 |
|
Estudiantes de Río Cuarto | 6 | 1 | 3 | 2 | 4:7 | -3 | 6 |
| 27 |
|
Gimnasia de Mendoza | 5 | 1 | 2 | 2 | 5:4 | 1 | 5 |
| 28 |
|
Ramón Santamarina | 6 | 1 | 2 | 3 | 6:7 | -1 | 5 |
| 29 |
|
Agropecuario Argentino | 6 | 1 | 2 | 3 | 4:5 | -1 | 5 |
| 30 |
|
Ferro Carril Oeste | 5 | 1 | 2 | 2 | 3:4 | -1 | 5 |
| 31 |
|
Flandria | 6 | 1 | 2 | 3 | 5:9 | -4 | 5 |
| 32 |
|
Tristan Suárez | 6 | 0 | 4 | 2 | 8:10 | -2 | 4 |
| 33 |
|
Temperley | 6 | 1 | 1 | 4 | 5:7 | -2 | 4 |
| 34 |
|
Deportivo Morón | 6 | 0 | 4 | 2 | 1:3 | -2 | 4 |
| 35 |
|
Güemes de SdE | 6 | 0 | 4 | 2 | 4:7 | -3 | 4 |
| 36 |
|
Villa Dálmine | 6 | 0 | 3 | 3 | 4:12 | -8 | 3 |
| 37 |
|
Mitre de SdE | 6 | 0 | 2 | 4 | 3:8 | -5 | 2 |
| Ascenso | |
| Playoff | |
| Playoff | |
| Descenso |
