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| 25.09.2021 | 20:30 | Gimnasia y Tiro de Salta | - | Boca Unidos | 1:0 (1:0) | |
| 20:30 | Sarmiento de Resistencia | - | Sportivo Las Parejas | 1:3 (1:3) | ||
| 20:30 | Defensores de Pronunciamiento | - | Gimnasia y Esgrima (CdU) | 1:0 (1:0) | ||
| 20:30 | Crucero del Norte | - | Central Norte | 0:0 (0:0) | ||
| 21:00 | Belgrano de San Francisco | - | Douglas Haig | 0:1 (0:0) | ||
| 21:00 | Defensores Belgrano (VR) | - | Racing de Córdoba | 2:1 (2:1) | ||
| 21:30 | Unión de Sunchales | - | Chaco For Ever | 0:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Gimnasia y Tiro de Salta | 23 | 14 | 7 | 2 | 31:15 | 16 | 49 |
| 2 |
|
Racing de Córdoba | 23 | 13 | 7 | 3 | 34:13 | 21 | 46 |
| 3 |
|
Central Norte | 23 | 9 | 11 | 3 | 32:21 | 11 | 38 |
| 4 |
|
Chaco For Ever | 23 | 9 | 10 | 4 | 28:17 | 11 | 37 |
| 5 |
|
Sportivo Las Parejas | 22 | 7 | 8 | 7 | 24:22 | 2 | 29 |
| 6 |
|
Defensores Belgrano (VR) | 22 | 8 | 5 | 9 | 27:30 | -3 | 29 |
| 7 |
|
Boca Unidos | 22 | 6 | 10 | 6 | 30:28 | 2 | 28 |
| 8 |
|
Juventud Unida de Gualeguaychú | 22 | 7 | 7 | 8 | 22:27 | -5 | 28 |
| 9 |
|
Unión de Sunchales | 22 | 6 | 9 | 7 | 22:24 | -2 | 27 |
| 10 |
|
Defensores de Pronunciamiento | 22 | 6 | 8 | 8 | 23:27 | -4 | 26 |
| 11 |
|
Sarmiento de Resistencia | 23 | 6 | 7 | 10 | 29:35 | -6 | 25 |
| 12 |
|
Douglas Haig | 22 | 6 | 4 | 12 | 13:19 | -6 | 22 |
| 13 |
|
Belgrano de San Francisco | 23 | 4 | 10 | 9 | 22:31 | -9 | 22 |
| 14 |
|
Gimnasia y Esgrima (CdU) | 22 | 6 | 4 | 12 | 17:29 | -12 | 22 |
| 15 |
|
Crucero del Norte | 22 | 4 | 7 | 11 | 15:31 | -16 | 19 |
| Playoff | |
| Próxima ronda |
