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| 25.09.2022 | 20:00 | Defensores de Pronunciamiento | - | Gimnasia y Esgrima (CdU) | 3:0 (3:0) | |
| 21:00 | Defensores Belgrano (VR) | - | Sarmiento de Resistencia | 0:1 (0:0) | ||
| 21:00 | San Martín de Formosa | - | Racing de Córdoba | 0:0 (0:0) | ||
| 21:00 | Sportivo Las Parejas | - | Crucero del Norte | 2:0 (1:0) | ||
| 21:30 | Gimnasia y Tiro de Salta | - | Boca Unidos | 2:0 (1:0) | ||
| 22:30 | Central Norte | - | Belgrano de San Francisco | 1:1 (0:1) | ||
| 26.09.2022 | 00:00 | Atlético Paraná | - | Juventud Antoniana | 1:3 (0:2) | |
| 27.09.2022 | 01:00 | Unión de Sunchales | - | Juventud Unida de Gualeguaychú | 2:1 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing de Córdoba | 29 | 18 | 9 | 2 | 49:14 | 35 | 63 |
| 2 |
|
Sarmiento de Resistencia | 29 | 18 | 8 | 3 | 41:15 | 26 | 62 |
| 3 |
|
San Martín de Formosa | 29 | 16 | 7 | 6 | 53:27 | 26 | 55 |
| 4 |
|
Central Norte | 29 | 15 | 9 | 5 | 42:23 | 19 | 54 |
| 5 |
|
Gimnasia y Tiro de Salta | 29 | 14 | 7 | 8 | 29:27 | 2 | 49 |
| 6 |
|
Douglas Haig | 29 | 12 | 7 | 10 | 39:30 | 9 | 43 |
| 7 |
|
Sportivo Las Parejas | 29 | 11 | 9 | 9 | 32:28 | 4 | 42 |
| 8 |
|
Belgrano de San Francisco | 29 | 11 | 6 | 12 | 36:33 | 3 | 39 |
| 9 |
|
Gimnasia y Esgrima (CdU) | 29 | 11 | 5 | 13 | 28:35 | -7 | 38 |
| 10 |
|
Crucero del Norte | 30 | 10 | 7 | 13 | 24:40 | -16 | 37 |
| 11 |
|
Juventud Antoniana | 30 | 10 | 7 | 13 | 29:39 | -10 | 37 |
| 12 |
|
Boca Unidos | 29 | 7 | 11 | 11 | 29:34 | -5 | 32 |
| 13 |
|
Defensores de Pronunciamiento | 29 | 7 | 9 | 13 | 25:35 | -10 | 30 |
| 14 |
|
Defensores Belgrano (VR) | 30 | 8 | 5 | 17 | 24:36 | -12 | 29 |
| 15 |
|
Unión de Sunchales | 29 | 8 | 5 | 16 | 29:45 | -16 | 29 |
| 16 |
|
Atlético Paraná | 29 | 5 | 7 | 17 | 22:44 | -22 | 22 |
| 17 |
|
Juventud Unida de Gualeguaychú | 29 | 6 | 4 | 19 | 25:51 | -26 | 22 |
| Playoff |
