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| 13.11.2021 | 11:00 | FSV Frankfurt | - | TSV 1860 München | 2:1 (1:0) | |
| 20.11.2021 | 11:00 | Stuttgart | - | SV Wehen Wiesbaden | 5:1 (1:1) | |
| 12:30 | SpVgg Greuther Fürth | - | SC Freiburg | 0:0 (0:0) | ||
| 13:00 | Stuttgarter Kickers | - | Darmstadt | 0:2 (0:2) | ||
| 21.11.2021 | 11:00 | SpVgg Unterhaching | - | Hoffenheim | 1:4 (0:2) | |
| 13:00 | Mainz | - | Karlsruher SC | 4:0 (3:0) | ||
| 13:00 | 1. FC Nürnberg | - | 1. FC Heidenheim 1846 | 6:3 (2:1) | ||
| 08.12.2021 | 19:00 | Ingolstadt | - | SSV Reutlingen | 2:2 (0:1) | |
| 13.02.2022 | 11:00 | Augsburgo | - | Eintracht Frankfurt | 3:1 (1:0) | |
| 01.03.2022 | 11:00 | Bayern Múnich | - | 1. FC Kaiserslautern | 1:2 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Stuttgart | 11 | 10 | 1 | 0 | 41:12 | 29 | 31 |
| 2 |
|
SpVgg Unterhaching | 11 | 9 | 0 | 2 | 31:16 | 15 | 27 |
| 3 |
|
Mainz | 11 | 7 | 3 | 1 | 32:12 | 20 | 24 |
| 4 |
|
SC Freiburg | 11 | 7 | 1 | 3 | 28:18 | 10 | 22 |
| 5 |
|
Bayern Múnich | 10 | 7 | 0 | 3 | 30:13 | 17 | 21 |
| 6 |
|
Hoffenheim | 10 | 7 | 0 | 3 | 32:18 | 14 | 21 |
| 7 |
|
Augsburgo | 10 | 7 | 0 | 3 | 24:17 | 7 | 21 |
| 8 |
|
1. FC Nürnberg | 11 | 6 | 1 | 4 | 31:20 | 11 | 19 |
| 9 |
|
SpVgg Greuther Fürth | 10 | 4 | 2 | 4 | 12:13 | -1 | 14 |
| 10 |
|
FSV Frankfurt | 11 | 4 | 2 | 5 | 14:16 | -2 | 14 |
| 11 |
|
Stuttgarter Kickers | 10 | 4 | 1 | 5 | 18:23 | -5 | 13 |
| 12 |
|
Eintracht Frankfurt | 11 | 3 | 3 | 5 | 15:20 | -5 | 12 |
| 13 |
|
Darmstadt | 11 | 4 | 0 | 7 | 16:29 | -13 | 12 |
| 14 |
|
1. FC Kaiserslautern | 11 | 3 | 2 | 6 | 25:26 | -1 | 11 |
| 15 |
|
Karlsruher SC | 10 | 3 | 2 | 5 | 14:16 | -2 | 11 |
| 16 |
|
1. FC Heidenheim 1846 | 10 | 3 | 2 | 5 | 22:32 | -10 | 11 |
| 17 |
|
TSV 1860 München | 10 | 3 | 1 | 6 | 10:15 | -5 | 10 |
| 18 |
|
SV Wehen Wiesbaden | 10 | 2 | 1 | 7 | 11:27 | -16 | 7 |
| 19 |
|
SV 07 Elversberg | 10 | 2 | 1 | 7 | 8:27 | -19 | 7 |
| 20 |
|
Ingolstadt | 10 | 1 | 3 | 6 | 10:26 | -16 | 6 |
| 21 |
|
SSV Reutlingen | 11 | 0 | 2 | 9 | 9:37 | -28 | 2 |
| Playoff | |
| Descenso |
