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| 12.03.2022 | 10:30 | 1. FC Heidenheim 1846 | - | SC Freiburg | 1:6 (0:4) | |
| 11:00 | Hoffenheim | - | Ingolstadt | 1:1 (1:0) | ||
| 13:00 | Karlsruher SC | - | SpVgg Greuther Fürth | 1:0 (0:0) | ||
| 14:00 | Mainz | - | 1. FC Nürnberg | 2:2 (1:2) | ||
| 13.03.2022 | SV 07 Elversberg | - | Stuttgarter Kickers | 0:2 | ||
| 11:00 | SpVgg Unterhaching | - | FSV Frankfurt | 3:2 (2:0) | ||
| 11:00 | Stuttgart | - | Bayern Múnich | 5:1 (3:0) | ||
| 11:00 | SV Wehen Wiesbaden | - | Augsburgo | 2:1 (2:0) | ||
| 13:00 | 1. FC Kaiserslautern | - | Eintracht Frankfurt | 2:0 (0:0) | ||
| 14:00 | TSV 1860 München | - | SSV Reutlingen | 2:1 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Stuttgart | 17 | 15 | 2 | 0 | 59:15 | 44 | 47 |
| 2 |
|
SpVgg Unterhaching | 17 | 14 | 0 | 3 | 42:25 | 17 | 42 |
| 3 |
|
Mainz | 17 | 10 | 5 | 2 | 47:20 | 27 | 35 |
| 4 |
|
Hoffenheim | 17 | 11 | 2 | 4 | 42:25 | 17 | 35 |
| 5 |
|
SC Freiburg | 17 | 11 | 1 | 5 | 51:28 | 23 | 34 |
| 6 |
|
Bayern Múnich | 17 | 10 | 2 | 5 | 47:26 | 21 | 32 |
| 7 |
|
Augsburgo | 17 | 9 | 2 | 6 | 36:28 | 8 | 29 |
| 8 |
|
1. FC Nürnberg | 18 | 8 | 3 | 7 | 46:29 | 17 | 27 |
| 9 |
|
SpVgg Greuther Fürth | 17 | 8 | 3 | 6 | 23:21 | 2 | 27 |
| 10 |
|
Darmstadt | 17 | 9 | 0 | 8 | 30:34 | -4 | 27 |
| 11 |
|
TSV 1860 München | 17 | 7 | 2 | 8 | 19:23 | -4 | 23 |
| 12 |
|
Karlsruher SC | 17 | 6 | 4 | 7 | 27:25 | 2 | 22 |
| 13 |
|
Stuttgarter Kickers | 17 | 7 | 1 | 9 | 25:32 | -7 | 22 |
| 14 |
|
1. FC Kaiserslautern | 18 | 6 | 2 | 10 | 40:41 | -1 | 20 |
| 15 |
|
FSV Frankfurt | 18 | 6 | 2 | 10 | 23:29 | -6 | 20 |
| 16 |
|
Eintracht Frankfurt | 17 | 5 | 4 | 8 | 22:28 | -6 | 19 |
| 17 |
|
1. FC Heidenheim 1846 | 17 | 5 | 4 | 8 | 30:44 | -14 | 19 |
| 18 |
|
Ingolstadt | 17 | 3 | 5 | 9 | 17:45 | -28 | 14 |
| 19 |
|
SV Wehen Wiesbaden | 17 | 4 | 1 | 12 | 19:44 | -25 | 13 |
| 20 |
|
SV 07 Elversberg | 17 | 2 | 1 | 14 | 8:51 | -43 | 7 |
| 21 |
|
SSV Reutlingen | 17 | 0 | 2 | 15 | 12:52 | -40 | 2 |
| Playoff | |
| Descenso |
