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| 11.11.2008 | 15:00 | Cercle Brugge | - | KFC Racing Mol Wezel | 2:1 | |
| 16:00 | KV Oostende | - | SV Zulte Waregem | 0:1 | ||
| 16:00 | FCV Dender EH | - | KFC Dessel Sport | 3:1 | ||
| 16:00 | Sporting Lokeren | - | Diegem Sport | 2:1 | ||
| 16:00 | KV Turnhout | - | KSV Roeselare | 1:4 | ||
| 16:00 | RAEC Mons | - | Lierse SK (old) | 0:2 | ||
| 18:00 | Excelsior Mouscron | - | AFC Tubize | 3:1 | ||
| 18:00 | RSC Anderlecht | - | RFC Tournai | 3:1 | ||
| 19:00 | KRC Genk | - | RFC Sérésien | 6:0 | ||
| 19:00 | Gante | - | Oud-Heverlee Leuven | 3:0 | ||
| 20:00 | KV Mechelen | - | Excelsior Veldwezelt | 4:2 | ||
| 20:00 | KVSK United | - | KVC Westerlo | 1:2 | ||
| 12.11.2008 | 20:00 | Sporting Charleroi | - | KSK Ronse | 3:1 | |
| 20:00 | Club Brugge KV | - | KSK Beveren | 1:0 | ||
| 20:30 | Germinal Beerschot | - | KRC Mechelen | 1:4 | ||
| 20:45 | KV Kortrijk | - | Standard Liège | 3:2 pn. |
