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| I | Jorge Wilstermann | - | Blooming | 3:0 (2:0) | ||
| V | Blooming | - | Jorge Wilstermann | 1:3 (1:3) | ||
| I: 06.05.2018 21:00 | V: 14.05.2018 01:30 | Campeones: Jorge Wilstermann | ||||
| I | Oriente Petrolero | - | The Strongest | 0:1 (0:0) | ||
| V | The Strongest | - | Oriente Petrolero | 5:1 (4:0) | ||
| I: 06.05.2018 21:00 | V: 12.05.2018 21:00 | Campeones: The Strongest | ||||
| I | Nacional Potosí | - | Bolívar | 1:2 (1:1) | ||
| V | Bolívar | - | Nacional Potosí | 1:0 (0:0) | ||
| I: 06.05.2018 23:15 | V: 13.05.2018 02:45 | Campeones: Bolívar | ||||
| I | Destroyers | - | Club San José | 1:0 (1:0) | ||
| V | Club San José | - | Destroyers | 4:2 (4:0, 8:0) pn. | ||
| I: 07.05.2018 01:30 | V: 12.05.2018 23:15 | Campeones: Club San José | ||||
