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| 27.03.2022 | 00:00 | La Higuera | - | Santiago Wanderers | 0:4 (0:2) | |
| 22:00 | General Velásquez | - | Santa Cruz | 3:0 (1:0) | ||
| 22:00 | Deportes Iberia | - | Deportes Temuco | 0:2 (0:0) | ||
| 22:00 | Provincial Ranco | - | Puerto Montt | 1:4 (1:2) | ||
| 22:30 | San Antonio Unido | - | San Luis | 6:5 (0:0, 0:0) pn. | ||
| 22:30 | San Bernardo Unido | - | CD Magallanes | 0:6 (0:1) | ||
| 23:00 | Provincial Ovalle | - | Deportes Copiapó | 3:2 (3:0) | ||
| 23:00 | Cobreloa | - | Deportes Iquique | 2:0 (0:0) | ||
| 23:00 | Independiente | - | Rangers | 4:3 (1:0, 2:2) pn. | ||
| 23:00 | CSD Lautaro | - | Santiago Morning | 0:1 (0:0) | ||
| 23:15 | Deportes Concepción | - | Fernández Vial | 0:2 (0:0) | ||
| 28.03.2022 | 02:00 | Trasandino de Los Andes | - | Unión San Felipe | 1:3 (0:0) | |
| 22:30 | Rodelindo Román | - | Deportes Melipilla | 0:2 (0:1) | ||
| 23:00 | Colo Colito | - | Universidad de Concepción | 0:9 (0:3) | ||
| 23:00 | Real San Joaquín | - | Barnechea | 0:3 (0:0) | ||
| 23:00 | Limache | - | Recoleta | 2:1 (1:1) |
