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| 02.10.2021 | 16:00 | Dynamo České Budějovice | - | FK Pardubice | 3:1 (2:1) | |
| 16:00 | Bohemians Praha 1905 | - | Sigma Olomouc | 2:0 (2:0) | ||
| 16:00 | 1. FC Slovácko | - | FK Teplice | 3:2 (1:1) | ||
| 19:00 | Viktoria Plzeň | - | FC Fastav Zlín | 2:1 (1:1) | ||
| 03.10.2021 | 16:00 | FC Hradec Králové | - | FK Jablonec | 2:2 (1:1) | |
| 16:00 | MFK Karviná | - | FK Mladá Boleslav | 0:1 (0:0) | ||
| 16:00 | Slovan Liberec | - | Baník Ostrava | 0:2 (0:1) | ||
| 19:00 | Sparta Praga | - | Slavia Praga | 1:0 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Viktoria Plzeň | 10 | 9 | 0 | 1 | 17:8 | 9 | 27 |
| 2 |
|
Slavia Praga | 10 | 8 | 1 | 1 | 25:8 | 17 | 25 |
| 3 |
|
Sparta Praga | 10 | 7 | 2 | 1 | 25:9 | 16 | 23 |
| 4 |
|
Baník Ostrava | 10 | 7 | 1 | 2 | 21:11 | 10 | 22 |
| 5 |
|
1. FC Slovácko | 10 | 7 | 1 | 2 | 19:11 | 8 | 22 |
| 6 |
|
Sigma Olomouc | 10 | 3 | 4 | 3 | 20:16 | 4 | 13 |
| 7 |
|
Dynamo České Budějovice | 10 | 4 | 1 | 5 | 13:13 | 0 | 13 |
| 8 |
|
FC Hradec Králové | 10 | 3 | 4 | 3 | 10:14 | -4 | 13 |
| 9 |
|
Bohemians Praha 1905 | 10 | 3 | 3 | 4 | 16:21 | -5 | 12 |
| 10 |
|
FK Mladá Boleslav | 10 | 3 | 2 | 5 | 16:17 | -1 | 11 |
| 11 |
|
FK Jablonec | 10 | 2 | 4 | 4 | 8:15 | -7 | 10 |
| 12 |
|
FC Fastav Zlín | 10 | 3 | 0 | 7 | 13:25 | -12 | 9 |
| 13 |
|
Slovan Liberec | 10 | 2 | 2 | 6 | 6:15 | -9 | 8 |
| 14 |
|
FK Pardubice | 10 | 1 | 3 | 6 | 13:19 | -6 | 6 |
| 15 |
|
FK Teplice | 10 | 1 | 2 | 7 | 9:20 | -11 | 5 |
| 16 |
|
MFK Karviná | 10 | 0 | 4 | 6 | 10:19 | -9 | 4 |
| Playoff | |
| Playoff | |
| Permanencia |
