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| 13.04.2022 | 16:30 | FK Fotbal Třinec | - | FK Varnsdorf | 1:1 (0:0) | |
| 16:30 | FK Dukla Praha | - | Viktoria Žižkov | 3:1 (2:1) | ||
| 16:30 | MFK Vyškov | - | 1. FK Příbram | 0:1 (0:0) | ||
| 16:30 | FC Sellier & Bellot Vlašim | - | AC Sparta Praha B | 1:1 (0:1) | ||
| 18:00 | Vysočina Jihlava | - | SK Líšeň | 1:0 (0:0) | ||
| 18:00 | SFC Opava | - | 1. SK Prostějov | 2:1 (1:1) | ||
| 19:00 | Zbrojovka Brno | - | FK Ústí nad Labem | 2:1 (2:0) | ||
| 04.05.2022 | 17:00 | MFK Chrudim | - | FK MAS Táborsko | 1:0 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zbrojovka Brno | 23 | 18 | 2 | 3 | 48:20 | 28 | 56 |
| 2 |
|
FC Sellier & Bellot Vlašim | 23 | 13 | 3 | 7 | 47:31 | 16 | 42 |
| 3 |
|
AC Sparta Praha B | 23 | 12 | 3 | 8 | 41:27 | 14 | 39 |
| 4 |
|
SK Líšeň | 23 | 11 | 6 | 6 | 37:26 | 11 | 39 |
| 5 |
|
SFC Opava | 23 | 11 | 6 | 6 | 35:24 | 11 | 39 |
| 6 |
|
FK Varnsdorf | 23 | 10 | 5 | 8 | 38:29 | 9 | 35 |
| 7 |
|
FK Dukla Praha | 23 | 10 | 5 | 8 | 33:31 | 2 | 35 |
| 8 |
|
Vysočina Jihlava | 23 | 8 | 6 | 9 | 19:26 | -7 | 30 |
| 9 |
|
1. SK Prostějov | 23 | 9 | 3 | 11 | 24:37 | -13 | 30 |
| 10 |
|
MFK Vyškov | 23 | 8 | 4 | 11 | 38:37 | 1 | 28 |
| 11 |
|
FK MAS Táborsko | 23 | 7 | 7 | 9 | 24:28 | -4 | 28 |
| 12 |
|
1. FK Příbram | 23 | 7 | 6 | 10 | 29:38 | -9 | 27 |
| 13 |
|
MFK Chrudim | 23 | 6 | 7 | 10 | 22:31 | -9 | 25 |
| 14 |
|
FK Fotbal Třinec | 23 | 7 | 4 | 12 | 24:38 | -14 | 25 |
| 15 |
|
FK Ústí nad Labem | 23 | 5 | 8 | 10 | 21:34 | -13 | 23 |
| 16 |
|
Viktoria Žižkov | 23 | 2 | 5 | 16 | 18:41 | -23 | 11 |
| Ascenso | |
| Playoff | |
| Descenso |
