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| 16.04.2021 | 20:00 | Chelsea | - | London City Lionesses | 5:0 | |
| 17.04.2021 | 13:00 | Manchester City WFC | - | Aston Villa | 8:0 | |
| 18.04.2021 | 13:30 | Birmingham City WFC | - | Coventry United | 5:1 | |
| 14:00 | West Ham United WFC | - | Chichester & Selsey LFC | 11:0 | ||
| 15:00 | Leicester City WFC | - | Liverpool | 1:0 | ||
| 15:00 | Middlesbrough WFC | - | Sheffield United LFC | 0:9 | ||
| 15:00 | Burnley FC | - | Manchester United WFC | 0:6 | ||
| 15:00 | Everton | - | Durham WFC | 2:1 | ||
| 15:00 | Reading WFC | - | Tottenham Hotspur WFC | 2:3 pró. | ||
| 15:00 | Oxford United | - | Charlton Athletic WFC | 1:2 pró. | ||
| 15:00 | Arsenal | - | Gillingham FC | 10:0 | ||
| 15:00 | Lewes FC Women | - | Southampton FC Women | 1:2 | ||
| 15:00 | Brighton & Hove Albion WFC | - | Bristol City WFC | 1:0 | ||
| 15:00 | Crystal Palace Women | - | London Bees LFC | 3:0 | ||
| 15:00 | Huddersfield Town LFC | - | Derby County LFC | 3:2 | ||
| 16:45 | Wolverhampton Wanderers | - | Blackburn Rovers WFC | 2:5 |
