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| 01.01.2022 | Niza | - | Paris FC / Olympique Lyon | no jug. | ||
| 02.01.2022 | 13:45 | AS Cannes | - | Toulouse | 0:1 (0:0) | |
| 13:45 | FC Versailles | - | La Roche VF | 4:0 (4:0) | ||
| 13:45 | Stade Brestois 29 | - | Girondins de Burdeos | 3:0 (1:0) | ||
| 13:45 | Nantes | - | AS Vitré | 2:0 (1:0) | ||
| 16:00 | Bergerac Périgord FC | - | US Créteil-Lusitanos | 5:4 (0:0, 0:0) pn. | ||
| 16:00 | AS Nancy Lorraine | - | Rennes | 4:3 (0:0, 1:1) pn. | ||
| 16:00 | Bastia | - | Clermont Foot 63 | 2:0 (1:0) | ||
| 16:00 | Montpellier | - | RC Strasbourg | 1:0 (1:0) | ||
| 18:30 | ESA Linas-Montlhéry | - | Amiens SC | 3:4 (0:0, 3:3) pn. | ||
| 18:30 | ES Thaon | - | Stade de Reims | 0:1 (0:0) | ||
| 18:30 | Jura Sud | - | Saint-Étienne | 1:4 (0:2) | ||
| 18:30 | US Quevilly-Rouen | - | Mónaco | 1:3 (1:2) | ||
| 21:00 | US Chauvigny | - | Marsella | 0:3 (0:2) | ||
| 03.01.2022 | 21:10 | Vannes OC | - | París Saint-Germain | 0:4 (0:1) | |
| 04.01.2022 | 21:00 | RC Lens | - | Lille | 4:3 (0:2, 2:2) pn. |
