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| 02.03.2022 | 16:00 | Deportivo Guastatoya | - | Nueva Concepción | 4:1 (2:0) | |
| 18:15 | Santa Lucía | - | Cobán Imperial | 2:1 (1:1) | ||
| 22:00 | Sololá FC | - | Xelaju MC | 1:0 (0:0) | ||
| 22:15 | Achuapa | - | Iztapa | 0:0 (0:0) | ||
| 03.03.2022 | 01:00 | Antigua GFC | - | CSD Municipal | 1:3 (0:0) | |
| 03:00 | Comunicaciones | - | Deportivo Malacateco | 2:0 (2:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guastatoya | 10 | 6 | 3 | 1 | 18:6 | 12 | 21 |
| 2 |
|
Comunicaciones | 10 | 5 | 3 | 2 | 23:13 | 10 | 18 |
| 3 |
|
CSD Municipal | 10 | 5 | 2 | 3 | 17:10 | 7 | 17 |
| 4 |
|
Cobán Imperial | 10 | 5 | 2 | 3 | 13:8 | 5 | 17 |
| 5 |
|
Antigua GFC | 10 | 5 | 2 | 3 | 14:10 | 4 | 17 |
| 6 |
|
Deportivo Malacateco | 10 | 5 | 2 | 3 | 13:10 | 3 | 17 |
| 7 |
|
Xelaju MC | 10 | 4 | 3 | 3 | 9:10 | -1 | 15 |
| 8 |
|
Santa Lucía | 10 | 4 | 1 | 5 | 14:15 | -1 | 13 |
| 9 |
|
Achuapa | 10 | 3 | 2 | 5 | 6:11 | -5 | 11 |
| 10 |
|
Iztapa | 10 | 2 | 3 | 5 | 10:16 | -6 | 9 |
| 11 |
|
Sololá FC | 10 | 1 | 3 | 6 | 4:14 | -10 | 6 |
| 12 |
|
Nueva Concepción | 10 | 1 | 2 | 7 | 10:28 | -18 | 5 |
| Playoff |
