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| 29.08.2021 | 03:00 | Xelaju MC | - | Deportivo Malacateco | 1:0 (0:0) | |
| 18:00 | Achuapa | - | Santa Lucía | 0:2 (0:1) | ||
| 19:00 | Comunicaciones | - | Deportivo Guastatoya | 3:1 (1:1) | ||
| 20:00 | Nueva Concepción | - | CSD Municipal | 0:2 (0:2) | ||
| 21:00 | Sololá FC | - | Iztapa | 1:0 (1:0) | ||
| 23:30 | Cobán Imperial | - | Antigua GFC | 0:2 (0:2) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Antigua GFC | 7 | 6 | 0 | 1 | 14:2 | 12 | 18 |
| 2 |
|
Comunicaciones | 7 | 5 | 1 | 1 | 17:7 | 10 | 16 |
| 3 |
|
Santa Lucía | 7 | 4 | 3 | 0 | 10:5 | 5 | 15 |
| 4 |
|
Xelaju MC | 7 | 4 | 2 | 1 | 7:5 | 2 | 14 |
| 5 |
|
CSD Municipal | 7 | 3 | 3 | 1 | 12:6 | 6 | 12 |
| 6 |
|
Sololá FC | 7 | 2 | 3 | 2 | 6:9 | -3 | 9 |
| 7 |
|
Iztapa | 7 | 2 | 1 | 4 | 7:8 | -1 | 7 |
| 8 |
|
Nueva Concepción | 7 | 2 | 1 | 4 | 4:11 | -7 | 7 |
| 9 |
|
Deportivo Guastatoya | 7 | 1 | 2 | 4 | 4:8 | -4 | 5 |
| 10 |
|
Cobán Imperial | 7 | 1 | 2 | 4 | 5:10 | -5 | 5 |
| 11 |
|
Deportivo Malacateco | 7 | 1 | 1 | 5 | 6:14 | -8 | 4 |
| 12 |
|
Achuapa | 7 | 0 | 3 | 4 | 3:10 | -7 | 3 |
| Playoff |
