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| 20.03.2022 | 14:30 | Campobasso | - | Latina Calcio | 2:0 (1:0) | |
| 14:30 | Fidelis Andria | - | Paganese Calcio | 1:0 (1:0) | ||
| 14:30 | Foggia Calcio | - | Calcio Catania | anu. | ||
| 14:30 | Monterosi FC | - | Juve Stabia | 3:0 (2:0) | ||
| 14:30 | Potenza | - | Palermo | 2:2 (1:0) | ||
| 14:30 | US Avellino | - | ACR Messina | 1:1 (1:0) | ||
| 14:30 | Vibonese Calcio | - | SSC Bari | 0:1 (0:0) | ||
| 15:15 | US Catanzaro | - | FC Turris | 2:0 (2:0) | ||
| 17:30 | Virtus Francavilla | - | AZ Picerno | 0:1 (0:0) | ||
| 06.04.2022 | 14:30 | Taranto FC | - | SS Monopoli 1966 | 2:0 (2:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SSC Bari | 31 | 20 | 7 | 4 | 50:24 | 26 | 67 |
| 2 |
|
US Catanzaro | 31 | 16 | 9 | 6 | 43:21 | 22 | 57 |
| 3 |
|
Palermo | 32 | 15 | 11 | 6 | 54:31 | 23 | 56 |
| 4 |
|
US Avellino | 31 | 14 | 13 | 4 | 40:22 | 18 | 55 |
| 5 |
|
Virtus Francavilla | 31 | 16 | 6 | 9 | 42:26 | 16 | 54 |
| 6 |
|
SS Monopoli 1966 | 31 | 14 | 7 | 10 | 32:27 | 5 | 49 |
| 7 |
|
Foggia Calcio | 31 | 11 | 13 | 7 | 50:40 | 10 | 46 |
| 8 |
|
FC Turris | 31 | 13 | 4 | 14 | 45:43 | 2 | 43 |
| 9 |
|
Monterosi FC | 31 | 11 | 10 | 10 | 37:36 | 1 | 43 |
| 10 |
|
AZ Picerno | 31 | 12 | 7 | 12 | 33:36 | -3 | 43 |
| 11 |
|
Latina Calcio | 32 | 11 | 8 | 13 | 36:40 | -4 | 41 |
| 12 |
|
Juve Stabia | 31 | 11 | 9 | 11 | 34:34 | 0 | 40 |
| 13 |
|
Campobasso | 31 | 10 | 9 | 12 | 40:48 | -8 | 39 |
| 14 |
|
Taranto FC | 32 | 8 | 12 | 12 | 29:37 | -8 | 36 |
| 15 |
|
Potenza | 32 | 7 | 11 | 14 | 32:46 | -14 | 32 |
| 16 |
|
ACR Messina | 32 | 8 | 8 | 16 | 37:55 | -18 | 32 |
| 17 |
|
Fidelis Andria | 31 | 6 | 9 | 16 | 25:40 | -15 | 27 |
| 18 |
|
Paganese Calcio | 31 | 6 | 7 | 18 | 30:55 | -25 | 25 |
| 19 |
|
Vibonese Calcio | 31 | 3 | 10 | 18 | 21:49 | -28 | 19 |
| 20 |
|
Calcio Catania | 0 | 0 | 0 | 0 | 0:0 | 0 | 0 |
| Ascenso | |
| Playoff | |
| Permanencia | |
| Descenso |
