 |
 |
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| 14.09.2021 | 15:00 | FC Olimpia | - | FC Sîngerei | 1:3 | |
| 15:00 | CS Cruiz-Plus | - | FCM Ungheni | 1:4 | ||
| 15:00 | ARF Ocniţa | - | Speranța Drochia | 0:4 | ||
| 15:00 | FC Real-Succes | - | Olimp Comrat | 1:8 | ||
| 15:00 | FC Saxan | - | Sporting Trestieni | 3:2 pró. | ||
| 15:00 | FC Maiak Chirsova | - | FC Cahul 2005 | 2:4 | ||
| 15:00 | Spartanii Sportul | - | Dacia Buiucani | 2:0 pró. | ||
| 15:00 | CF Soroca | - | Victoria Bardar | 0:1 |
