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| 22.01.2022 | 16:30 | Club Necaxa | - | Cruz Azul | 4:1 (2:1) | |
| 18:00 | UANL Tigres | - | Santos Laguna | 2:1 (0:1) | ||
| 18:30 | Pumas UNAM | - | FC Juárez | 2:1 (1:1) | ||
| 18:30 | Atlas Guadalajara | - | CF Monterrey | 2:1 (2:0) | ||
| 18:30 | Gallos Blancos | - | Deportivo Toluca | 1:1 (1:0) | ||
| 21:45 | Club Tijuana | - | Atlético San Luis | 5:0 (2:0) | ||
| 23:00 | Deportivo Guadalajara | - | Club León | 4:0 (3:0) | ||
| 09.02.2022 | 23:00 | CF América | - | Puebla FC | 1:0 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pumas UNAM | 3 | 3 | 0 | 0 | 6:3 | 3 | 9 |
| 2 |
|
CF Pachuca | 2 | 2 | 0 | 0 | 6:1 | 5 | 6 |
| 3 |
|
CF América | 3 | 2 | 0 | 1 | 6:2 | 4 | 6 |
| 4 |
|
Deportivo Toluca | 3 | 1 | 1 | 1 | 3:4 | -1 | 4 |
| 5 |
|
Club Necaxa | 2 | 1 | 0 | 1 | 5:3 | 2 | 3 |
| 6 |
|
FC Juárez | 2 | 1 | 0 | 1 | 3:2 | 1 | 3 |
| 7 |
|
Gallos Blancos | 3 | 0 | 2 | 1 | 1:5 | -4 | 2 |
| 8 |
|
Puebla FC | 3 | 0 | 1 | 2 | 0:3 | -3 | 1 |
| 9 |
|
Cruz Azul | 3 | 0 | 0 | 3 | 3:10 | -7 | 0 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Tijuana | 3 | 3 | 0 | 0 | 10:3 | 7 | 9 |
| 2 |
|
Deportivo Guadalajara | 3 | 2 | 1 | 0 | 7:1 | 6 | 7 |
| 3 |
|
Atlas Guadalajara | 3 | 2 | 0 | 1 | 7:3 | 4 | 6 |
| 4 |
|
UANL Tigres | 2 | 2 | 0 | 0 | 5:2 | 3 | 6 |
| 5 |
|
Santos Laguna | 2 | 1 | 0 | 1 | 3:3 | 0 | 3 |
| 6 |
|
Atlético San Luis | 3 | 1 | 0 | 2 | 2:8 | -6 | 3 |
| 7 |
|
CF Monterrey | 3 | 0 | 1 | 2 | 3:5 | -2 | 1 |
| 8 |
|
Mazatlán FC | 2 | 0 | 0 | 2 | 1:6 | -5 | 0 |
| 9 |
|
Club León | 3 | 0 | 0 | 3 | 3:10 | -7 | 0 |
| Playoff | |
| Playoff |
