 |
 |
|
| 02.10.2021 | 16:00 | Cruz Azul | - | Gallos Blancos | 1:0 (1:0) | |
| 16:00 | Deportivo Toluca | - | Club Tijuana | 2:0 (1:0) | ||
| 16:00 | Atlas Guadalajara | - | CF Monterrey | 3:1 (2:0) | ||
| 18:00 | CF Pachuca | - | Puebla FC | 1:1 (1:1) | ||
| 18:00 | Mazatlán FC | - | UANL Tigres | 1:1 (0:0) | ||
| 19:00 | Club Necaxa | - | Deportivo Guadalajara | 0:1 (0:0) | ||
| 23:00 | Atlético San Luis | - | Santos Laguna | 0:3 (0:2) | ||
| 20.10.2021 | 16:00 | CF América | - | Pumas UNAM | 1:2 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 10 | 7 | 2 | 1 | 30:10 | 20 | 23 |
| 2 |
|
Santos Laguna | 10 | 6 | 3 | 1 | 24:11 | 13 | 21 |
| 3 |
|
Deportivo Toluca | 10 | 6 | 3 | 1 | 17:11 | 6 | 21 |
| 4 |
|
Pumas UNAM | 10 | 6 | 2 | 2 | 18:10 | 8 | 20 |
| 5 |
|
Cruz Azul | 10 | 6 | 1 | 3 | 13:10 | 3 | 19 |
| 6 |
|
CF Pachuca | 10 | 5 | 3 | 2 | 11:8 | 3 | 18 |
| 7 |
|
Atlas Guadalajara | 10 | 5 | 0 | 5 | 27:21 | 6 | 15 |
| 8 |
|
Club Necaxa | 9 | 4 | 2 | 3 | 12:8 | 4 | 14 |
| 9 |
|
CF Monterrey | 10 | 4 | 2 | 4 | 16:15 | 1 | 14 |
| 10 |
|
UANL Tigres | 10 | 4 | 2 | 4 | 15:16 | -1 | 14 |
| 11 |
|
Club Tijuana | 9 | 4 | 1 | 4 | 9:12 | -3 | 13 |
| 12 |
|
Puebla FC | 10 | 3 | 2 | 5 | 16:18 | -2 | 11 |
| 13 |
|
Club León | 9 | 3 | 1 | 5 | 13:17 | -4 | 10 |
| 14 |
|
Mazatlán FC | 10 | 3 | 1 | 6 | 15:31 | -16 | 10 |
| 15 |
|
CF América | 10 | 3 | 0 | 7 | 12:14 | -2 | 9 |
| 16 |
|
Gallos Blancos | 10 | 2 | 2 | 6 | 11:14 | -3 | 8 |
| 17 |
|
FC Juárez | 9 | 1 | 2 | 6 | 7:17 | -10 | 5 |
| 18 |
|
Atlético San Luis | 10 | 1 | 1 | 8 | 8:31 | -23 | 4 |
| Playoff |
