 |
 |
|
| 18.09.2021 | 16:00 | UANL Tigres | - | Atlético San Luis | 2:0 (1:0) | |
| 16:00 | Atlas Guadalajara | - | Deportivo Guadalajara | 2:4 (1:2) | ||
| 18:00 | CF Pachuca | - | Deportivo Toluca | 0:0 (0:0) | ||
| 18:00 | FC Juárez | - | Puebla FC | 1:3 (0:2) | ||
| 19:00 | Club Necaxa | - | Santos Laguna | 1:1 (1:1) | ||
| 19:00 | Club Tijuana | - | Pumas UNAM | 1:0 (1:0) | ||
| 23:00 | CF América | - | Cruz Azul | 1:2 (0:1) | ||
| 19.09.2021 | 17:00 | Mazatlán FC | - | Club León | 0:4 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 8 | 6 | 1 | 1 | 28:9 | 19 | 19 |
| 2 |
|
Santos Laguna | 8 | 5 | 3 | 0 | 20:9 | 11 | 18 |
| 3 |
|
Deportivo Toluca | 8 | 5 | 2 | 1 | 13:9 | 4 | 17 |
| 4 |
|
Cruz Azul | 8 | 5 | 1 | 2 | 11:8 | 3 | 16 |
| 5 |
|
Club Necaxa | 8 | 4 | 2 | 2 | 12:7 | 5 | 14 |
| 6 |
|
Pumas UNAM | 8 | 4 | 2 | 2 | 13:9 | 4 | 14 |
| 7 |
|
CF Pachuca | 8 | 4 | 2 | 2 | 8:6 | 2 | 14 |
| 8 |
|
Club Tijuana | 8 | 4 | 1 | 3 | 9:10 | -1 | 13 |
| 9 |
|
CF Monterrey | 8 | 3 | 2 | 3 | 11:12 | -1 | 11 |
| 10 |
|
UANL Tigres | 8 | 3 | 1 | 4 | 12:14 | -2 | 10 |
| 11 |
|
Club León | 8 | 3 | 1 | 4 | 12:15 | -3 | 10 |
| 12 |
|
Atlas Guadalajara | 8 | 3 | 0 | 5 | 22:19 | 3 | 9 |
| 13 |
|
Puebla FC | 8 | 3 | 0 | 5 | 13:15 | -2 | 9 |
| 14 |
|
Mazatlán FC | 8 | 3 | 0 | 5 | 14:26 | -12 | 9 |
| 15 |
|
Gallos Blancos | 8 | 2 | 2 | 4 | 10:11 | -1 | 8 |
| 16 |
|
CF América | 8 | 2 | 0 | 6 | 9:11 | -2 | 6 |
| 17 |
|
FC Juárez | 8 | 1 | 2 | 5 | 7:14 | -7 | 5 |
| 18 |
|
Atlético San Luis | 8 | 1 | 0 | 7 | 7:27 | -20 | 3 |
| Playoff |
