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| 07.05.2022 | 16:00 | Deportivo Guadalajara | - | UANL Tigres | 4:3 (3:1) | |
| 16:00 | Cruz Azul | - | Club Necaxa | 2:4 (2:2) | ||
| 16:00 | Gallos Blancos | - | CF Pachuca | 2:2 (2:1) | ||
| 16:00 | Santos Laguna | - | Club León | 2:1 (1:0) | ||
| 16:00 | Pumas UNAM | - | Puebla FC | 1:1 (0:0) | ||
| 16:00 | Atlas Guadalajara | - | Atlético San Luis | 4:2 (2:1) | ||
| 23:00 | CF América | - | FC Juárez | 3:3 (2:1) | ||
| 23:00 | CF Monterrey | - | Club Tijuana | 3:1 (2:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Necaxa | 16 | 10 | 4 | 2 | 32:22 | 10 | 34 |
| 2 |
|
CF América | 16 | 9 | 2 | 5 | 25:19 | 6 | 29 |
| 3 |
|
Deportivo Toluca | 16 | 8 | 3 | 5 | 37:22 | 15 | 27 |
| 4 |
|
Pumas UNAM | 16 | 8 | 3 | 5 | 25:15 | 10 | 27 |
| 5 |
|
Cruz Azul | 16 | 8 | 2 | 6 | 34:26 | 8 | 26 |
| 6 |
|
CF Pachuca | 16 | 4 | 7 | 5 | 27:28 | -1 | 19 |
| 7 |
|
Puebla FC | 16 | 5 | 3 | 8 | 25:25 | 0 | 18 |
| 8 |
|
FC Juárez | 16 | 3 | 2 | 11 | 20:47 | -27 | 11 |
| 9 |
|
Gallos Blancos | 16 | 2 | 4 | 10 | 11:32 | -21 | 10 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 16 | 12 | 3 | 1 | 42:16 | 26 | 39 |
| 2 |
|
Atlas Guadalajara | 16 | 9 | 5 | 2 | 39:21 | 18 | 32 |
| 3 |
|
Santos Laguna | 16 | 9 | 2 | 5 | 27:18 | 9 | 29 |
| 4 |
|
UANL Tigres | 16 | 6 | 5 | 5 | 23:27 | -4 | 23 |
| 5 |
|
CF Monterrey | 16 | 5 | 6 | 5 | 26:25 | 1 | 21 |
| 6 |
|
Club León | 16 | 6 | 2 | 8 | 20:25 | -5 | 20 |
| 7 |
|
Mazatlán FC | 16 | 4 | 3 | 9 | 20:37 | -17 | 15 |
| 8 |
|
Club Tijuana | 16 | 4 | 1 | 11 | 13:27 | -14 | 13 |
| 9 |
|
Atlético San Luis | 16 | 2 | 3 | 11 | 17:31 | -14 | 9 |
| Playoff | |
| Playoff |
