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| 22.01.2022 | 16:00 | Pumas UNAM | - | FC Juárez | 3:0 (1:0) | |
| 16:00 | UANL Tigres | - | Santos Laguna | 0:2 (0:1) | ||
| 16:00 | Atlas Guadalajara | - | CF Monterrey | 2:2 (2:1) | ||
| 16:00 | Gallos Blancos | - | Deportivo Toluca | 2:2 (1:1) | ||
| 19:00 | Club Necaxa | - | Cruz Azul | 2:1 (1:0) | ||
| 19:00 | Club Tijuana | - | Atlético San Luis | 2:0 (0:0) | ||
| 23:00 | Deportivo Guadalajara | - | Club León | 2:1 (0:0) | ||
| 09.02.2022 | 23:00 | CF América | - | Puebla FC | 1:0 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 3 | 3 | 0 | 0 | 5:0 | 5 | 9 |
| 2 |
|
Cruz Azul | 3 | 2 | 0 | 1 | 7:5 | 2 | 6 |
| 3 |
|
Deportivo Toluca | 3 | 1 | 1 | 1 | 10:6 | 4 | 4 |
| 4 |
|
Puebla FC | 3 | 1 | 1 | 1 | 4:3 | 1 | 4 |
| 5 |
|
Pumas UNAM | 3 | 1 | 0 | 2 | 4:3 | 1 | 3 |
| 6 |
|
FC Juárez | 2 | 1 | 0 | 1 | 3:4 | -1 | 3 |
| 7 |
|
Club Necaxa | 2 | 1 | 0 | 1 | 3:8 | -5 | 3 |
| 8 |
|
CF Pachuca | 2 | 0 | 1 | 1 | 4:6 | -2 | 1 |
| 9 |
|
Gallos Blancos | 3 | 0 | 1 | 2 | 2:7 | -5 | 1 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlas Guadalajara | 3 | 2 | 1 | 0 | 6:2 | 4 | 7 |
| 2 |
|
Deportivo Guadalajara | 3 | 1 | 2 | 0 | 5:4 | 1 | 5 |
| 3 |
|
Santos Laguna | 2 | 1 | 1 | 0 | 2:0 | 2 | 4 |
| 4 |
|
Club Tijuana | 3 | 1 | 1 | 1 | 4:5 | -1 | 4 |
| 5 |
|
CF Monterrey | 3 | 0 | 3 | 0 | 4:4 | 0 | 3 |
| 6 |
|
Mazatlán FC | 2 | 1 | 0 | 1 | 2:2 | 0 | 3 |
| 7 |
|
UANL Tigres | 2 | 1 | 0 | 1 | 1:2 | -1 | 3 |
| 8 |
|
Club León | 3 | 0 | 1 | 2 | 3:5 | -2 | 1 |
| 9 |
|
Atlético San Luis | 3 | 0 | 1 | 2 | 2:5 | -3 | 1 |
| Playoff | |
| Playoff |
