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| 03.09.2022 | 16:00 | Pumas UNAM | - | Gallos Blancos | 0:1 (0:0) | |
| 16:00 | Atlas Guadalajara | - | UANL Tigres | 2:0 (2:0) | ||
| 16:00 | Santos Laguna | - | Club León | 5:1 (3:1) | ||
| 16:00 | Atlético San Luis | - | Club Tijuana | 1:0 (0:0) | ||
| 16:00 | Club Necaxa | - | Deportivo Toluca | 3:2 (0:1) | ||
| 17:00 | FC Juárez | - | Puebla FC | 4:1 (0:0) | ||
| 18:00 | CF Pachuca | - | Cruz Azul | 3:1 (2:1) | ||
| 19:30 | Mazatlán FC | - | Deportivo Guadalajara | 1:2 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Necaxa | 10 | 6 | 3 | 1 | 28:11 | 17 | 21 |
| 2 |
|
Cruz Azul | 10 | 4 | 3 | 3 | 21:15 | 6 | 15 |
| 3 |
|
CF América | 9 | 4 | 3 | 2 | 18:13 | 5 | 15 |
| 4 |
|
Pumas UNAM | 10 | 4 | 3 | 3 | 12:13 | -1 | 15 |
| 5 |
|
FC Juárez | 10 | 3 | 4 | 3 | 14:14 | 0 | 13 |
| 6 |
|
CF Pachuca | 10 | 4 | 1 | 5 | 13:18 | -5 | 13 |
| 7 |
|
Deportivo Toluca | 9 | 3 | 2 | 4 | 24:22 | 2 | 11 |
| 8 |
|
Gallos Blancos | 10 | 3 | 1 | 6 | 11:22 | -11 | 10 |
| 9 |
|
Puebla FC | 10 | 2 | 2 | 6 | 14:27 | -13 | 8 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 10 | 7 | 2 | 1 | 20:11 | 9 | 23 |
| 2 |
|
Santos Laguna | 10 | 7 | 1 | 2 | 18:9 | 9 | 22 |
| 3 |
|
Mazatlán FC | 10 | 6 | 1 | 3 | 13:11 | 2 | 19 |
| 4 |
|
CF Monterrey | 9 | 6 | 0 | 3 | 20:10 | 10 | 18 |
| 5 |
|
Atlas Guadalajara | 10 | 4 | 2 | 4 | 13:13 | 0 | 14 |
| 6 |
|
Atlético San Luis | 10 | 3 | 2 | 5 | 17:20 | -3 | 11 |
| 7 |
|
Club Tijuana | 10 | 3 | 2 | 5 | 10:13 | -3 | 11 |
| 8 |
|
UANL Tigres | 9 | 2 | 0 | 7 | 7:14 | -7 | 6 |
| 9 |
|
Club León | 10 | 0 | 2 | 8 | 10:27 | -17 | 2 |
| Playoff | |
| Playoff |
