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| 20.08.2022 | 16:00 | Puebla FC | - | Pumas UNAM | 1:3 (1:2) | |
| 16:00 | Deportivo Guadalajara | - | Mazatlán FC | 3:1 (0:1) | ||
| 19:00 | Club Tijuana | - | Atlético San Luis | 3:2 (1:1) | ||
| 23:00 | CF América | - | CF Pachuca | 4:0 (1:0) | ||
| 06.09.2022 | 16:00 | UANL Tigres | - | Atlas Guadalajara | 0:1 (0:0) | |
| 07.09.2022 | 17:00 | Gallos Blancos | - | Deportivo Toluca | 1:3 (0:2) | |
| 21.09.2022 | 16:00 | Club León | - | Santos Laguna | 0:0 (0:0) | |
| 28.09.2022 | 16:00 | Cruz Azul | - | Club Necaxa | 1:0 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Necaxa | 8 | 4 | 3 | 1 | 21:8 | 13 | 15 |
| 2 |
|
Pumas UNAM | 8 | 4 | 3 | 1 | 12:8 | 4 | 15 |
| 3 |
|
CF América | 8 | 4 | 2 | 2 | 17:12 | 5 | 14 |
| 4 |
|
Cruz Azul | 8 | 3 | 3 | 2 | 16:12 | 4 | 12 |
| 5 |
|
Deportivo Toluca | 8 | 3 | 2 | 3 | 22:19 | 3 | 11 |
| 6 |
|
CF Pachuca | 8 | 3 | 1 | 4 | 10:16 | -6 | 10 |
| 7 |
|
FC Juárez | 8 | 2 | 3 | 3 | 9:12 | -3 | 9 |
| 8 |
|
Gallos Blancos | 8 | 2 | 1 | 5 | 9:18 | -9 | 7 |
| 9 |
|
Puebla FC | 8 | 1 | 2 | 5 | 12:23 | -11 | 5 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Santos Laguna | 8 | 6 | 1 | 1 | 13:7 | 6 | 19 |
| 2 |
|
Deportivo Guadalajara | 8 | 5 | 2 | 1 | 17:10 | 7 | 17 |
| 3 |
|
Mazatlán FC | 8 | 5 | 1 | 2 | 11:9 | 2 | 16 |
| 4 |
|
CF Monterrey | 8 | 5 | 0 | 3 | 17:10 | 7 | 15 |
| 5 |
|
Club Tijuana | 8 | 3 | 2 | 3 | 10:11 | -1 | 11 |
| 6 |
|
Atlas Guadalajara | 8 | 3 | 1 | 4 | 7:9 | -2 | 10 |
| 7 |
|
Atlético San Luis | 8 | 2 | 2 | 4 | 16:17 | -1 | 8 |
| 8 |
|
UANL Tigres | 8 | 2 | 0 | 6 | 7:12 | -5 | 6 |
| 9 |
|
Club León | 8 | 0 | 1 | 7 | 5:18 | -13 | 1 |
| Playoff | |
| Playoff |
