 |
 |
|
|
| 01.10.2021 | 16:00 | Puebla FC | - | CF Pachuca | 1:1 (1:1) | |
| 17:00 | FC Juárez | - | CF Monterrey | 1:0 (1:0) | ||
| 02.10.2021 | 16:00 | Deportivo Guadalajara | - | Atlas Guadalajara | 0:2 (0:1) | |
| 16:00 | Club León | - | Atlético San Luis | 2:0 (1:0) | ||
| 17:30 | Santos Laguna | - | Mazatlán FC | 4:2 (3:0) | ||
| 03.10.2021 | 16:00 | CF América | - | Pumas UNAM | 0:0 (0:0) | |
| 16:00 | Deportivo Toluca | - | Gallos Blancos | 2:0 (0:0) | ||
| 16:00 | UANL Tigres | - | Club Necaxa | 3:2 (2:0) | ||
| 04.10.2021 | 00:45 | Club Tijuana | - | Cruz Azul | 0:1 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Toluca | 12 | 7 | 2 | 3 | 19:11 | 8 | 23 |
| 2 |
|
Santos Laguna | 12 | 6 | 3 | 3 | 25:18 | 7 | 21 |
| 3 |
|
CF América | 12 | 5 | 5 | 2 | 20:15 | 5 | 20 |
| 4 |
|
Atlas Guadalajara | 12 | 6 | 2 | 4 | 18:16 | 2 | 20 |
| 5 |
|
Club León | 12 | 6 | 2 | 4 | 14:12 | 2 | 20 |
| 6 |
|
Cruz Azul | 12 | 4 | 6 | 2 | 10:7 | 3 | 18 |
| 7 |
|
UANL Tigres | 12 | 5 | 2 | 5 | 17:15 | 2 | 17 |
| 8 |
|
Deportivo Guadalajara | 12 | 5 | 2 | 5 | 16:19 | -3 | 17 |
| 9 |
|
Club Necaxa | 12 | 4 | 4 | 4 | 20:18 | 2 | 16 |
| 10 |
|
Club Tijuana | 12 | 4 | 4 | 4 | 18:18 | 0 | 16 |
| 11 |
|
CF Pachuca | 12 | 3 | 6 | 3 | 13:13 | 0 | 15 |
| 12 |
|
Gallos Blancos | 12 | 4 | 3 | 5 | 14:15 | -1 | 15 |
| 13 |
|
Mazatlán FC | 12 | 4 | 3 | 5 | 21:26 | -5 | 15 |
| 14 |
|
CF Monterrey | 12 | 4 | 2 | 6 | 17:17 | 0 | 14 |
| 15 |
|
Atlético San Luis | 12 | 4 | 2 | 6 | 20:21 | -1 | 14 |
| 16 |
|
Puebla FC | 12 | 3 | 5 | 4 | 20:24 | -4 | 14 |
| 17 |
|
Pumas UNAM | 12 | 3 | 3 | 6 | 17:23 | -6 | 12 |
| 18 |
|
FC Juárez | 12 | 1 | 4 | 7 | 9:20 | -11 | 7 |
| Playoff |
