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| 30.10.2010 | 14:00 | FK Pelister | - | FK Renova | 0:1 (0:0) | |
| 14:00 | Sileks Kratovo | - | FK Turnovo | 0:2 (0:1) | ||
| 14:00 | Metalurg Skopje | - | Vardar Skopje | 1:0 (0:0) | ||
| 14:00 | FK Bregalnica Štip | - | Napredok Kičevo | 4:2 (3:1) | ||
| 31.10.2010 | 13:00 | FK Rabotnički | - | FK Skopje | 1:1 (1:1) | |
| 03.11.2010 | 13:00 | FK Teteks | - | KF Shkëndija 79 | 1:0 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Metalurg Skopje | 12 | 6 | 4 | 2 | 15:7 | 8 | 22 |
| 2 |
|
FK Renova | 12 | 6 | 4 | 2 | 12:6 | 6 | 22 |
| 3 |
|
KF Shkëndija 79 | 12 | 6 | 3 | 3 | 19:7 | 12 | 21 |
| 4 |
|
FK Teteks | 12 | 5 | 5 | 2 | 12:8 | 4 | 20 |
| 5 |
|
FK Rabotnički | 12 | 5 | 4 | 3 | 15:11 | 4 | 19 |
| 6 |
|
FK Turnovo | 12 | 6 | 1 | 5 | 14:12 | 2 | 19 |
| 7 |
|
Sileks Kratovo | 12 | 5 | 3 | 4 | 14:16 | -2 | 18 |
| 8 |
|
FK Skopje | 12 | 5 | 2 | 5 | 11:10 | 1 | 17 |
| 9 |
|
FK Bregalnica Štip | 12 | 5 | 1 | 6 | 12:16 | -4 | 16 |
| 10 |
|
Napredok Kičevo | 12 | 4 | 3 | 5 | 12:13 | -1 | 15 |
| 11 |
|
FK Pelister | 12 | 1 | 2 | 9 | 6:23 | -17 | 5 |
| 12 |
|
Vardar Skopje | 12 | 2 | 0 | 10 | 7:20 | -13 | 3 |
| CL Ronda previa | |
| Europa League | |
| Permanencia | |
| Descenso |
