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| 05.10.2022 | 14:00 | FC Struga | - | FK Rabotnički | 2:1 | |
| 14:00 | FK Bregalnica Štip | - | FK Pelister | 1:0 | ||
| 14:00 | Vardar Skopje | - | FK Fortuna | 4:0 | ||
| 14:00 | FK AP Brera Strumica | - | FK Ljuboten | 9:0 | ||
| 14:00 | KF Shkupi | - | FK Voska Sport | 6:0 | ||
| 14:00 | KF Shkëndija 79 | - | FK Skopje | 5:0 | ||
| 14:00 | GFK Tikvesh | - | Sileks Kratovo | 0:1 | ||
| 19.10.2022 | 14:00 | FK Pobeda Junior | - | Makedonija GP | 0:2 |
