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| 03.12.2021 | 20:00 | Almere City FC | - | FC Eindhoven | 2:0 (1:0) | |
| 20:00 | FC Den Bosch | - | NAC Breda | 0:5 (0:1) | ||
| 20:00 | FC Dordrecht | - | Roda JC Kerkrade | 2:5 (1:1) | ||
| 20:00 | Helmond Sport | - | FC Volendam | 1:1 (1:1) | ||
| 20:00 | MVV | - | TOP Oss | 1:1 (0:1) | ||
| 20:00 | Telstar | - | VVV-Venlo | 1:3 (0:1) | ||
| 06.12.2021 | 20:00 | Jong Ajax | - | FC Emmen | 1:0 (0:0) | |
| 20:00 | AZ Alkmaar (J) | - | SBV Excelsior | 0:2 (0:0) | ||
| 20:00 | FC Utrecht (J) | - | ADO Den Haag | 1:4 (0:2) | ||
| 20:00 | Jong PSV | - | De Graafschap | 2:3 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Volendam | 18 | 11 | 6 | 1 | 44:23 | 21 | 39 |
| 2 |
|
SBV Excelsior | 18 | 12 | 2 | 4 | 45:24 | 21 | 38 |
| 3 |
|
Jong Ajax | 18 | 11 | 2 | 5 | 43:30 | 13 | 35 |
| 4 |
|
FC Emmen | 18 | 10 | 3 | 5 | 27:14 | 13 | 33 |
| 5 |
|
De Graafschap | 18 | 10 | 3 | 5 | 31:22 | 9 | 33 |
| 6 |
|
ADO Den Haag | 18 | 12 | 2 | 4 | 41:21 | 20 | 32 |
| 7 |
|
FC Eindhoven | 18 | 9 | 2 | 7 | 32:26 | 6 | 29 |
| 8 |
|
Roda JC Kerkrade | 18 | 7 | 6 | 5 | 34:25 | 9 | 27 |
| 9 |
|
NAC Breda | 18 | 7 | 5 | 6 | 30:22 | 8 | 26 |
| 10 |
|
FC Den Bosch | 18 | 8 | 1 | 9 | 20:31 | -11 | 25 |
| 11 |
|
VVV-Venlo | 18 | 7 | 2 | 9 | 20:23 | -3 | 23 |
| 12 |
|
MVV | 18 | 7 | 2 | 9 | 21:37 | -16 | 23 |
| 13 |
|
Jong PSV | 18 | 6 | 4 | 8 | 27:29 | -2 | 22 |
| 14 |
|
AZ Alkmaar (J) | 18 | 6 | 3 | 9 | 14:19 | -5 | 21 |
| 15 |
|
FC Utrecht (J) | 18 | 5 | 4 | 9 | 22:30 | -8 | 19 |
| 16 |
|
Telstar | 18 | 4 | 6 | 8 | 21:38 | -17 | 18 |
| 17 |
|
Almere City FC | 18 | 4 | 4 | 10 | 30:39 | -9 | 16 |
| 18 |
|
TOP Oss | 18 | 3 | 5 | 10 | 19:30 | -11 | 14 |
| 19 |
|
Helmond Sport | 18 | 4 | 4 | 10 | 16:29 | -13 | 13 |
| 20 |
|
FC Dordrecht | 18 | 2 | 4 | 12 | 21:46 | -25 | 10 |
| Ascenso | |
| Playoff | |
| Playoff |
