 |
 |
|
| 28.05.2021 | 23:45 | Sol de América | - | Guaireña FC | 0:0 (0:0) | |
| 29.05.2021 | 02:00 | Guaraní | - | Cerro Porteño | 2:0 (1:0) | |
| 23:45 | Sportivo Luqueño | - | Libertad | 1:3 (0:3) | ||
| 30.05.2021 | 23:45 | River Plate | - | Club Olimpia | 1:2 (0:1) | |
| 31.05.2021 | 02:00 | 12 de Octubre de Itauguá | - | Club Nacional | 2:2 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Libertad | 18 | 12 | 2 | 4 | 36:15 | 21 | 38 |
| 2 |
|
Club Olimpia | 18 | 10 | 3 | 5 | 34:23 | 11 | 33 |
| 3 |
|
Club Nacional | 18 | 8 | 6 | 4 | 26:19 | 7 | 30 |
| 4 |
|
Cerro Porteño | 18 | 8 | 4 | 6 | 24:22 | 2 | 28 |
| 5 |
|
Guaireña FC | 18 | 6 | 8 | 4 | 20:14 | 6 | 26 |
| 6 |
|
Guaraní | 18 | 7 | 4 | 7 | 24:27 | -3 | 25 |
| 7 |
|
12 de Octubre de Itauguá | 18 | 5 | 7 | 6 | 20:25 | -5 | 22 |
| 8 |
|
Sportivo Luqueño | 18 | 5 | 3 | 10 | 19:29 | -10 | 18 |
| 9 |
|
Sol de América | 18 | 3 | 5 | 10 | 18:28 | -10 | 14 |
| 10 |
|
River Plate | 18 | 2 | 6 | 10 | 13:32 | -19 | 12 |
| Copa Libertadores |
