 |
 |
|
|
| 23.04.2022 | 23:30 | Libertad | - | 12 de Octubre de Itauguá | 4:0 (0:0) | |
| 24.04.2022 | 02:15 | General Caballero DJLM | - | Club Olimpia | 2:3 (2:0) | |
| 23:30 | Sportivo Ameliano | - | Cerro Porteño | 0:1 (0:0) | ||
| 25.04.2022 | 01:45 | Guaraní | - | Guaireña FC | 2:1 (0:1) | |
| 26.04.2022 | 00:00 | Tacuary | - | Resistencia SC | 3:1 (2:0) | |
| 02:15 | Club Nacional | - | Sol de América | 0:3 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Libertad | 12 | 9 | 2 | 1 | 29:12 | 17 | 29 |
| 2 |
|
Cerro Porteño | 12 | 9 | 1 | 2 | 24:8 | 16 | 28 |
| 3 |
|
Club Olimpia | 12 | 6 | 3 | 3 | 18:13 | 5 | 21 |
| 4 |
|
Resistencia SC | 12 | 5 | 5 | 2 | 22:19 | 3 | 20 |
| 5 |
|
Sol de América | 12 | 5 | 2 | 5 | 12:15 | -3 | 17 |
| 6 |
|
Club Nacional | 12 | 5 | 2 | 5 | 16:20 | -4 | 17 |
| 7 |
|
Tacuary | 12 | 5 | 1 | 6 | 12:12 | 0 | 16 |
| 8 |
|
Guaraní | 12 | 4 | 2 | 6 | 13:15 | -2 | 14 |
| 9 |
|
Guaireña FC | 12 | 3 | 3 | 6 | 11:17 | -6 | 12 |
| 10 |
|
General Caballero DJLM | 12 | 2 | 3 | 7 | 12:17 | -5 | 9 |
| 11 |
|
Sportivo Ameliano | 12 | 3 | 0 | 9 | 12:20 | -8 | 9 |
| 12 |
|
12 de Octubre de Itauguá | 12 | 1 | 6 | 5 | 8:21 | -13 | 9 |
| Copa Libertadores |
