 |
 |
|
|
| 09.10.2022 | 22:00 | Sportivo Ameliano | - | Club Olimpia | 0:2 (0:2) | |
| 10.10.2022 | 00:30 | Libertad | - | 12 de Octubre de Itauguá | 2:2 (1:1) | |
| 22:00 | Guaireña FC | - | Resistencia SC | 3:2 (2:1) | ||
| 11.10.2022 | 00:30 | Club Nacional | - | Cerro Porteño | 0:0 (0:0) | |
| 12.10.2022 | 22:00 | Tacuary | - | General Caballero DJLM | 0:3 (0:1) | |
| 13.10.2022 | 22:00 | Guaraní | - | Sol de América | 4:1 (3:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Cerro Porteño | 16 | 10 | 5 | 1 | 23:8 | 15 | 35 |
| 2 |
|
Club Nacional | 16 | 10 | 5 | 1 | 22:11 | 11 | 35 |
| 3 |
|
Club Olimpia | 16 | 10 | 3 | 3 | 26:14 | 12 | 33 |
| 4 |
|
Libertad | 16 | 8 | 2 | 6 | 28:21 | 7 | 26 |
| 5 |
|
Guaireña FC | 16 | 6 | 4 | 6 | 22:21 | 1 | 22 |
| 6 |
|
Guaraní | 16 | 5 | 5 | 6 | 17:20 | -3 | 20 |
| 7 |
|
Resistencia SC | 16 | 5 | 5 | 6 | 13:18 | -5 | 20 |
| 8 |
|
General Caballero DJLM | 16 | 5 | 3 | 8 | 18:22 | -4 | 18 |
| 9 |
|
Tacuary | 16 | 5 | 3 | 8 | 13:19 | -6 | 18 |
| 10 |
|
Sportivo Ameliano | 16 | 5 | 2 | 9 | 18:21 | -3 | 17 |
| 11 |
|
Sol de América | 16 | 5 | 2 | 9 | 17:26 | -9 | 17 |
| 12 |
|
12 de Octubre de Itauguá | 16 | 2 | 1 | 13 | 10:26 | -16 | 7 |
| Copa Libertadores |
