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| 28.11.2010 | 12:00 | Terek Grozny | - | Sibir Novosibirsk | 1:1 (1:0) | |
| 12:00 | FK Saturn | - | Spartak Vladikavkaz | 1:1 (1:1) | ||
| 12:00 | Lokomotiv Moskva | - | Rubin Kazan | 0:0 (0:0) | ||
| 12:00 | FK Tom Tomsk | - | FK Rostov | 3:1 (0:0) | ||
| 12:00 | Spartak Nalchik | - | Anzhi Makhachkala | 1:3 (0:1) | ||
| 12:00 | Dinamo Moskva | - | Spartak Moskva | 1:1 (1:1) | ||
| 12:00 | Zenit | - | Krylia Sovetov | 0:0 (0:0) | ||
| 12:00 | FK Amkar Perm | - | CSKA Moscú | 0:0 (0:0) |
| » Clasificación | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zenit | 30 | 20 | 8 | 2 | 61:21 | 40 | 68 |
| 2 |
|
CSKA Moscú | 30 | 18 | 8 | 4 | 51:22 | 29 | 62 |
| 3 |
|
Rubin Kazan | 30 | 15 | 13 | 2 | 37:16 | 21 | 58 |
| 4 |
|
Spartak Moskva | 30 | 13 | 10 | 7 | 43:33 | 10 | 49 |
| 5 |
|
Lokomotiv Moskva | 30 | 13 | 9 | 8 | 34:29 | 5 | 48 |
| 6 |
|
Spartak Nalchik | 30 | 12 | 8 | 10 | 40:37 | 3 | 44 |
| 7 |
|
Dinamo Moskva | 30 | 9 | 13 | 8 | 38:31 | 7 | 40 |
| 8 |
|
FK Tom Tomsk | 30 | 10 | 7 | 13 | 35:43 | -8 | 37 |
| 9 |
|
FK Saturn | 30 | 8 | 10 | 12 | 27:38 | -11 | 34 |
| 10 |
|
FK Rostov | 30 | 10 | 4 | 16 | 27:44 | -17 | 34 |
| 11 |
|
Terek Grozny | 30 | 8 | 9 | 13 | 28:34 | -6 | 33 |
| 12 |
|
Anzhi Makhachkala | 30 | 9 | 6 | 15 | 29:39 | -10 | 33 |
| 13 |
|
Krylia Sovetov | 30 | 7 | 10 | 13 | 28:40 | -12 | 31 |
| 14 |
|
FK Amkar Perm | 30 | 8 | 6 | 16 | 24:35 | -11 | 30 |
| 15 |
|
Spartak Vladikavkaz | 30 | 7 | 9 | 14 | 25:41 | -16 | 30 |
| 16 |
|
Sibir Novosibirsk | 30 | 4 | 8 | 18 | 34:58 | -24 | 20 |
| Champions League | |
| CL Ronda previa | |
| Europa League | |
| Descenso |
