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| 19.11.2021 | 17:00 | Zenit | - | FK Nizhny Novgorod | 5:1 (3:1) | |
| 20.11.2021 | 12:00 | Krylia Sovetov | - | FK Ural | 1:1 (0:0) | |
| 14:30 | Lokomotiv Moskva | - | Akhmat Grozny | 1:2 (0:1) | ||
| 17:00 | FK Krasnodar | - | Spartak Moskva | 2:1 (1:1) | ||
| 21.11.2021 | 12:00 | FK Rostov | - | FK Ufa | 2:2 (1:1) | |
| 12:00 | CSKA Moscú | - | FK Khimki | 0:0 (0:0) | ||
| 14:30 | Dinamo Moskva | - | Arsenal Tula | 5:1 (4:0) | ||
| 17:30 | FK Sochi | - | Rubin Kazan | 1:2 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zenit | 15 | 10 | 3 | 2 | 39:17 | 22 | 33 |
| 2 |
|
Dinamo Moskva | 15 | 9 | 2 | 4 | 27:17 | 10 | 29 |
| 3 |
|
FK Sochi | 15 | 9 | 0 | 6 | 25:18 | 7 | 27 |
| 4 |
|
Lokomotiv Moskva | 15 | 6 | 7 | 2 | 21:15 | 6 | 25 |
| 5 |
|
FK Krasnodar | 15 | 7 | 3 | 5 | 24:14 | 10 | 24 |
| 6 |
|
CSKA Moscú | 15 | 7 | 3 | 5 | 18:14 | 4 | 24 |
| 7 |
|
Krylia Sovetov | 15 | 7 | 2 | 6 | 20:17 | 3 | 23 |
| 8 |
|
Rubin Kazan | 15 | 6 | 4 | 5 | 20:20 | 0 | 22 |
| 9 |
|
Akhmat Grozny | 15 | 7 | 0 | 8 | 17:21 | -4 | 21 |
| 10 |
|
Spartak Moskva | 15 | 5 | 4 | 6 | 17:21 | -4 | 19 |
| 11 |
|
FK Rostov | 15 | 4 | 5 | 6 | 27:27 | 0 | 17 |
| 12 |
|
FK Ufa | 15 | 3 | 6 | 6 | 16:21 | -5 | 15 |
| 13 |
|
FK Nizhny Novgorod | 15 | 4 | 2 | 9 | 16:29 | -13 | 14 |
| 14 |
|
FK Khimki | 15 | 2 | 7 | 6 | 11:22 | -11 | 13 |
| 15 |
|
Arsenal Tula | 15 | 3 | 4 | 8 | 16:31 | -15 | 13 |
| 16 |
|
FK Ural | 15 | 2 | 6 | 7 | 6:16 | -10 | 12 |
| Permanencia | |
| Descenso |
