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| 15.04.2022 | 10:00 | FK Rostov | - | CSKA Moskva | 1:1 (0:1) | |
| 12:00 | FK Chertanovo | - | Spartak Moskva | 4:1 (0:1) | ||
| 13:00 | Zenit St. Petersburg | - | Krylia Sovetov | 2:0 (1:0) | ||
| 15:00 | FK Sochi | - | Rubin Kazan | 1:0 (1:0) | ||
| 16:00 | Lokomotiv Moskva | - | Dinamo Moskva | 2:1 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CSKA Moskva | 23 | 17 | 2 | 4 | 50:19 | 31 | 53 |
| 2 |
|
FK Rostov | 23 | 16 | 3 | 4 | 58:21 | 37 | 51 |
| 3 |
|
Lokomotiv Moskva | 23 | 14 | 4 | 5 | 40:24 | 16 | 46 |
| 4 |
|
Zenit St. Petersburg | 23 | 14 | 1 | 8 | 55:30 | 25 | 43 |
| 5 |
|
FK Chertanovo | 23 | 12 | 4 | 7 | 40:28 | 12 | 40 |
| 6 |
|
Dinamo Moskva | 23 | 13 | 1 | 9 | 45:36 | 9 | 40 |
| 7 |
|
Spartak Moskva | 23 | 12 | 3 | 8 | 36:26 | 10 | 39 |
| 8 |
|
FK Sochi | 23 | 12 | 1 | 10 | 36:35 | 1 | 37 |
| 9 |
|
Krylia Sovetov | 23 | 11 | 3 | 9 | 28:36 | -8 | 36 |
| 10 |
|
Rubin Kazan | 23 | 9 | 6 | 8 | 44:36 | 8 | 33 |
