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| 29.04.2022 | 12:00 | Lokomotiv Moskva | - | Rubin Kazan | 0:2 (0:0) | |
| 15:00 | FK Sochi | - | Dinamo Moskva | 2:0 (1:0) | ||
| 15:00 | FK Rostov | - | Krylia Sovetov | 3:0 (1:0) | ||
| 16:30 | FK Chertanovo | - | CSKA Moskva | 1:2 (1:1) | ||
| 18:30 | Zenit St. Petersburg | - | Spartak Moskva | 1:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CSKA Moskva | 25 | 19 | 2 | 4 | 54:21 | 33 | 59 |
| 2 |
|
FK Rostov | 25 | 17 | 4 | 4 | 62:22 | 40 | 55 |
| 3 |
|
Lokomotiv Moskva | 25 | 15 | 4 | 6 | 41:26 | 15 | 49 |
| 4 |
|
Zenit St. Petersburg | 25 | 15 | 1 | 9 | 57:32 | 25 | 46 |
| 5 |
|
FK Chertanovo | 25 | 12 | 5 | 8 | 41:30 | 11 | 41 |
| 6 |
|
Dinamo Moskva | 25 | 13 | 2 | 10 | 45:38 | 7 | 41 |
| 7 |
|
FK Sochi | 25 | 13 | 2 | 10 | 41:38 | 3 | 41 |
| 8 |
|
Spartak Moskva | 25 | 12 | 3 | 10 | 36:28 | 8 | 39 |
| 9 |
|
Krylia Sovetov | 25 | 11 | 4 | 10 | 31:42 | -11 | 37 |
| 10 |
|
Rubin Kazan | 25 | 10 | 7 | 8 | 47:37 | 10 | 37 |
