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| 13.05.2022 | 10:00 | FK Rostov | - | Dinamo Moskva | 2:1 (1:1) | |
| 11:00 | Zenit St. Petersburg | - | Rubin Kazan | 3:3 (3:0) | ||
| 12:00 | FK Sochi | - | Spartak Moskva | 2:1 (1:1) | ||
| 12:00 | FK Chertanovo | - | Krylia Sovetov | 2:2 (2:1) | ||
| 16:00 | Lokomotiv Moskva | - | CSKA Moskva | 1:1 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CSKA Moskva | 27 | 20 | 3 | 4 | 57:22 | 35 | 63 |
| 2 |
|
FK Rostov | 27 | 18 | 5 | 4 | 65:24 | 41 | 59 |
| 3 |
|
Lokomotiv Moskva | 27 | 16 | 5 | 6 | 45:28 | 17 | 53 |
| 4 |
|
Zenit St. Petersburg | 27 | 16 | 2 | 9 | 63:35 | 28 | 50 |
| 5 |
|
FK Chertanovo | 27 | 13 | 6 | 8 | 46:32 | 14 | 45 |
| 6 |
|
FK Sochi | 27 | 14 | 2 | 11 | 43:41 | 2 | 44 |
| 7 |
|
Dinamo Moskva | 27 | 13 | 2 | 12 | 46:43 | 3 | 41 |
| 8 |
|
Spartak Moskva | 27 | 12 | 4 | 11 | 38:31 | 7 | 40 |
| 9 |
|
Krylia Sovetov | 27 | 11 | 5 | 11 | 34:47 | -13 | 38 |
| 10 |
|
Rubin Kazan | 27 | 10 | 8 | 9 | 50:43 | 7 | 38 |
