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| 12.11.2008 | 13:00 | OFK Beograd | - | FK Sinđelić Beograd | 2:0 | |
| 13:00 | ČSK Pivara | - | Crvena Zvezda | 0:2 | ||
| 13:00 | Borac Čačak | - | Sloboda Užice | 3:4 pn. | ||
| 13:00 | Hajduk Beograd | - | Vojvodina | 6:5 pn. | ||
| 13:00 | FK Rad Beograd | - | FK Napredak | 3:4 pn. | ||
| 13:00 | FK Smederevo | - | FK Bežanija | 1:0 | ||
| 13:00 | FK Javor | - | FK Banat Zrenjanin | 0:2 | ||
| 16:30 | Partizan | - | FK Jagodina | 4:2 |
