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| 25.02.2022 | 18:00 | Denizlispor | - | Boluspor | 2:0 (1:0) | |
| 26.02.2022 | 11:30 | Keçiörengücü | - | Tuzlaspor | 1:0 (1:0) | |
| 11:30 | Manisa FK | - | Eyüpspor | 2:1 (1:0) | ||
| 17:00 | Gençlerbirliği | - | Balıkesirspor | 2:0 (1:0) | ||
| 27.02.2022 | 11:30 | Bandırmaspor | - | Adanaspor | 1:0 (1:0) | |
| 11:30 | Ümraniyespor | - | Samsunspor | 3:1 (1:0) | ||
| 14:00 | BB Erzurumspor | - | MKE Ankaragücü | 0:1 (0:1) | ||
| 17:00 | İstanbulspor AŞ | - | Kocaelispor | 1:1 (0:0) | ||
| 28.02.2022 | 18:00 | Menemen Belediyespor | - | Altınordu FK | 0:1 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
MKE Ankaragücü | 26 | 17 | 4 | 5 | 41:19 | 22 | 55 |
| 2 |
|
Ümraniyespor | 26 | 16 | 4 | 6 | 46:26 | 20 | 52 |
| 3 |
|
Bandırmaspor | 26 | 14 | 4 | 8 | 39:23 | 16 | 46 |
| 4 |
|
Eyüpspor | 26 | 12 | 9 | 5 | 40:28 | 12 | 45 |
| 5 |
|
BB Erzurumspor | 26 | 12 | 8 | 6 | 40:30 | 10 | 44 |
| 6 |
|
İstanbulspor AŞ | 25 | 13 | 4 | 8 | 41:29 | 12 | 43 |
| 7 |
|
Samsunspor | 25 | 10 | 9 | 6 | 41:30 | 11 | 39 |
| 8 |
|
Manisa FK | 26 | 10 | 6 | 10 | 30:31 | -1 | 36 |
| 9 |
|
Boluspor | 25 | 9 | 7 | 9 | 28:27 | 1 | 34 |
| 10 |
|
Tuzlaspor | 25 | 9 | 7 | 9 | 23:23 | 0 | 34 |
| 11 |
|
Keçiörengücü | 25 | 9 | 7 | 9 | 33:34 | -1 | 34 |
| 12 |
|
Adanaspor | 26 | 9 | 7 | 10 | 29:27 | 2 | 34 |
| 13 |
|
Gençlerbirliği | 26 | 10 | 3 | 13 | 31:41 | -10 | 33 |
| 14 |
|
Kocaelispor | 25 | 8 | 5 | 12 | 24:32 | -8 | 29 |
| 15 |
|
Menemen Belediyespor | 26 | 6 | 11 | 9 | 29:40 | -11 | 29 |
| 16 |
|
Denizlispor | 26 | 7 | 6 | 13 | 25:39 | -14 | 27 |
| 17 |
|
Altınordu FK | 26 | 8 | 1 | 17 | 29:51 | -22 | 25 |
| 18 |
|
Bursaspor | 25 | 6 | 6 | 13 | 26:38 | -12 | 24 |
| 19 |
|
Balıkesirspor | 25 | 3 | 2 | 20 | 19:46 | -27 | 11 |
| Ascenso | |
| Playoff | |
| Descenso |
