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| 11.12.2021 | 11:00 | Ankaraspor | - | Somaspor | 1:0 (0:0) | |
| 11:00 | Turgutluspor | - | Etimesgut Belediyespor | 1:0 (0:0) | ||
| 12.12.2021 | 11:00 | Adıyamanspor | - | Sarıyer SK | 1:0 (0:0) | |
| 11:00 | Afjet Afyonspor | - | Bayburt İl Özel İdare | 2:1 (0:1) | ||
| 11:00 | Diyarbekirspor | - | Sivas Belediyespor | 0:0 (0:0) | ||
| 11:00 | Ergene Velimeşe | - | Kahramanmaraşspor | 2:2 (2:0) | ||
| 11:00 | Hekimoğlu Trabzon | - | Vanspor FK | 1:0 (0:0) | ||
| 11:00 | Inegölspor | - | Bodrum FK | 1:2 (1:2) | ||
| 11:00 | Niğde Anadolu FK | - | Çorum FK | 0:2 (0:1) | ||
| 11:00 | Sakaryaspor | - | Serik Belediyespor | 2:1 (2:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sakaryaspor | 17 | 11 | 6 | 0 | 32:6 | 26 | 39 |
| 2 |
|
Hekimoğlu Trabzon | 17 | 10 | 7 | 0 | 30:10 | 20 | 37 |
| 3 |
|
Sivas Belediyespor | 17 | 9 | 4 | 4 | 32:13 | 19 | 31 |
| 4 |
|
Afjet Afyonspor | 17 | 8 | 7 | 2 | 35:19 | 16 | 31 |
| 5 |
|
Çorum FK | 17 | 8 | 7 | 2 | 24:9 | 15 | 31 |
| 6 |
|
Bodrum FK | 17 | 9 | 3 | 5 | 28:14 | 14 | 30 |
| 7 |
|
Bayburt İl Özel İdare | 17 | 9 | 3 | 5 | 24:17 | 7 | 30 |
| 8 |
|
Ankaraspor | 17 | 8 | 5 | 4 | 29:18 | 11 | 29 |
| 9 |
|
Somaspor | 17 | 7 | 5 | 5 | 26:22 | 4 | 26 |
| 10 |
|
Vanspor FK | 17 | 7 | 5 | 5 | 23:24 | -1 | 26 |
| 11 |
|
Inegölspor | 17 | 7 | 3 | 7 | 20:23 | -3 | 24 |
| 12 |
|
Serik Belediyespor | 17 | 7 | 2 | 8 | 23:25 | -2 | 23 |
| 13 |
|
Turgutluspor | 17 | 5 | 6 | 6 | 20:27 | -7 | 21 |
| 14 |
|
Etimesgut Belediyespor | 17 | 5 | 5 | 7 | 18:24 | -6 | 20 |
| 15 |
|
Diyarbekirspor | 17 | 5 | 4 | 8 | 18:21 | -3 | 19 |
| 16 |
|
Sarıyer SK | 17 | 4 | 3 | 10 | 16:25 | -9 | 15 |
| 17 |
|
Adıyamanspor | 17 | 4 | 1 | 12 | 20:32 | -12 | 13 |
| 18 |
|
Ergene Velimeşe | 17 | 3 | 3 | 11 | 15:36 | -21 | 12 |
| 19 |
|
Kahramanmaraşspor | 17 | 2 | 1 | 14 | 12:46 | -34 | 7 |
| 20 |
|
Niğde Anadolu FK | 17 | 1 | 2 | 14 | 10:44 | -34 | 5 |
| Ascenso | |
| Playoff | |
| Descenso |
