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| 18.12.2021 | 11:00 | Bodrum FK | - | Niğde Anadolu FK | 1:1 (0:0) | |
| 11:00 | Kahramanmaraşspor | - | Sakaryaspor | 0:5 (0:3) | ||
| 11:00 | Sarıyer SK | - | Afjet Afyonspor | 1:2 (1:1) | ||
| 19.12.2021 | 11:00 | Ankaraspor | - | Etimesgut Belediyespor | 2:2 (2:1) | |
| 11:00 | Bayburt İl Özel İdare | - | Diyarbekirspor | 2:1 (2:0) | ||
| 11:00 | Çorum FK | - | Adıyamanspor | 3:0 (1:0) | ||
| 11:00 | Serik Belediyespor | - | Turgutluspor | 3:0 (2:0) | ||
| 11:00 | Sivas Belediyespor | - | Ergene Velimeşe | 3:1 (2:0) | ||
| 11:00 | Somaspor | - | Hekimoğlu Trabzon | 3:0 (0:0) | ||
| 11:00 | Vanspor FK | - | Inegölspor | 3:1 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sakaryaspor | 18 | 12 | 6 | 0 | 37:6 | 31 | 42 |
| 2 |
|
Hekimoğlu Trabzon | 18 | 10 | 7 | 1 | 30:13 | 17 | 37 |
| 3 |
|
Sivas Belediyespor | 18 | 10 | 4 | 4 | 35:14 | 21 | 34 |
| 4 |
|
Çorum FK | 18 | 9 | 7 | 2 | 27:9 | 18 | 34 |
| 5 |
|
Afjet Afyonspor | 18 | 9 | 7 | 2 | 37:20 | 17 | 34 |
| 6 |
|
Bayburt İl Özel İdare | 18 | 10 | 3 | 5 | 26:18 | 8 | 33 |
| 7 |
|
Bodrum FK | 18 | 9 | 4 | 5 | 29:15 | 14 | 31 |
| 8 |
|
Ankaraspor | 18 | 8 | 6 | 4 | 31:20 | 11 | 30 |
| 9 |
|
Somaspor | 18 | 8 | 5 | 5 | 29:22 | 7 | 29 |
| 10 |
|
Vanspor FK | 18 | 8 | 5 | 5 | 26:25 | 1 | 29 |
| 11 |
|
Serik Belediyespor | 18 | 8 | 2 | 8 | 26:25 | 1 | 26 |
| 12 |
|
Inegölspor | 18 | 7 | 3 | 8 | 21:26 | -5 | 24 |
| 13 |
|
Etimesgut Belediyespor | 18 | 5 | 6 | 7 | 20:26 | -6 | 21 |
| 14 |
|
Turgutluspor | 18 | 5 | 6 | 7 | 20:30 | -10 | 21 |
| 15 |
|
Diyarbekirspor | 18 | 5 | 4 | 9 | 19:23 | -4 | 19 |
| 16 |
|
Sarıyer SK | 18 | 4 | 3 | 11 | 17:27 | -10 | 15 |
| 17 |
|
Adıyamanspor | 18 | 4 | 1 | 13 | 20:35 | -15 | 13 |
| 18 |
|
Ergene Velimeşe | 18 | 3 | 3 | 12 | 16:39 | -23 | 12 |
| 19 |
|
Kahramanmaraşspor | 18 | 2 | 1 | 15 | 12:51 | -39 | 7 |
| 20 |
|
Niğde Anadolu FK | 18 | 1 | 3 | 14 | 11:45 | -34 | 6 |
| Ascenso | |
| Playoff | |
| Descenso |
