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| 15.01.2022 | 11:00 | Etimesgut Belediyespor | - | 1461 Trabzon FK | 2:0 (1:0) | |
| 11:00 | Turgutluspor | - | Sivas Belediyespor | 0:2 (0:2) | ||
| 16.01.2022 | 11:00 | Adıyamanspor | - | Vanspor FK | 3:1 (2:1) | |
| 11:00 | Afjet Afyonspor | - | Bodrum FK | 0:2 (0:2) | ||
| 11:00 | Diyarbekirspor | - | Çorum FK | 2:0 (2:0) | ||
| 11:00 | Ergene Velimeşe | - | Sarıyer SK | 3:0 (1:0) | ||
| 11:00 | Inegölspor | - | Ankaraspor | 3:1 (1:0) | ||
| 11:00 | Niğde Anadolu FK | - | Somaspor | 1:3 (0:1) | ||
| 11:00 | Sakaryaspor | - | Bayburt İl Özel İdare | 2:0 (0:0) | ||
| 11:00 | Serik Belediyespor | - | Kahramanmaraşspor | 0:3 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sakaryaspor | 20 | 14 | 6 | 0 | 43:8 | 35 | 48 |
| 2 |
|
1461 Trabzon FK | 20 | 11 | 7 | 2 | 32:16 | 16 | 40 |
| 3 |
|
Sivas Belediyespor | 20 | 11 | 4 | 5 | 39:18 | 21 | 37 |
| 4 |
|
Afjet Afyonspor | 20 | 10 | 7 | 3 | 40:23 | 17 | 37 |
| 5 |
|
Bayburt İl Özel İdare | 20 | 11 | 3 | 6 | 28:21 | 7 | 36 |
| 6 |
|
Somaspor | 20 | 10 | 5 | 5 | 33:23 | 10 | 35 |
| 7 |
|
Bodrum FK | 20 | 10 | 4 | 6 | 32:18 | 14 | 34 |
| 8 |
|
Çorum FK | 20 | 9 | 7 | 4 | 28:14 | 14 | 34 |
| 9 |
|
Vanspor FK | 20 | 9 | 5 | 6 | 28:28 | 0 | 32 |
| 10 |
|
Ankaraspor | 20 | 8 | 6 | 6 | 33:25 | 8 | 30 |
| 11 |
|
Serik Belediyespor | 20 | 9 | 2 | 9 | 27:28 | -1 | 29 |
| 12 |
|
Inegölspor | 20 | 8 | 3 | 9 | 24:28 | -4 | 27 |
| 13 |
|
Diyarbekirspor | 20 | 7 | 4 | 9 | 24:24 | 0 | 25 |
| 14 |
|
Etimesgut Belediyespor | 20 | 6 | 6 | 8 | 22:27 | -5 | 24 |
| 15 |
|
Turgutluspor | 20 | 5 | 7 | 8 | 20:32 | -12 | 22 |
| 16 |
|
Adıyamanspor | 20 | 6 | 1 | 13 | 26:37 | -11 | 19 |
| 17 |
|
Sarıyer SK | 20 | 4 | 3 | 13 | 18:33 | -15 | 15 |
| 18 |
|
Ergene Velimeşe | 20 | 4 | 3 | 13 | 20:41 | -21 | 15 |
| 19 |
|
Kahramanmaraşspor | 20 | 3 | 2 | 15 | 15:51 | -36 | 11 |
| 20 |
|
Niğde Anadolu FK | 20 | 1 | 3 | 16 | 12:49 | -37 | 6 |
| Ascenso | |
| Playoff | |
| Descenso |
