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| 22.01.2022 | 11:00 | Ankaraspor | - | Niğde Anadolu FK | 1:1 (0:0) | |
| 11:00 | Bayburt İl Özel İdare | - | Turgutluspor | 0:0 (0:0) | ||
| 11:00 | Bodrum FK | - | Diyarbekirspor | 1:0 (0:0) | ||
| 11:00 | Çorum FK | - | Ergene Velimeşe | 1:2 (1:2) | ||
| 11:00 | 1461 Trabzon FK | - | Inegölspor | 1:0 (1:0) | ||
| 11:00 | Kahramanmaraşspor | - | Etimesgut Belediyespor | 0:0 (0:0) | ||
| 11:00 | Sarıyer SK | - | Sakaryaspor | 4:1 (0:1) | ||
| 11:00 | Sivas Belediyespor | - | Serik Belediyespor | 2:1 (0:0) | ||
| 09.02.2022 | 11:00 | Somaspor | - | Adıyamanspor | 1:3 (0:2) | |
| 11:00 | Vanspor FK | - | Afjet Afyonspor | 2:1 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sakaryaspor | 21 | 14 | 6 | 1 | 44:12 | 32 | 48 |
| 2 |
|
1461 Trabzon FK | 21 | 12 | 7 | 2 | 33:16 | 17 | 43 |
| 3 |
|
Sivas Belediyespor | 21 | 12 | 4 | 5 | 41:19 | 22 | 40 |
| 4 |
|
Afjet Afyonspor | 21 | 10 | 7 | 4 | 41:25 | 16 | 37 |
| 5 |
|
Bodrum FK | 21 | 11 | 4 | 6 | 33:18 | 15 | 37 |
| 6 |
|
Bayburt İl Özel İdare | 21 | 11 | 4 | 6 | 28:21 | 7 | 37 |
| 7 |
|
Somaspor | 21 | 10 | 5 | 6 | 34:26 | 8 | 35 |
| 8 |
|
Vanspor FK | 21 | 10 | 5 | 6 | 30:29 | 1 | 35 |
| 9 |
|
Çorum FK | 21 | 9 | 7 | 5 | 29:16 | 13 | 34 |
| 10 |
|
Ankaraspor | 21 | 8 | 7 | 6 | 34:26 | 8 | 31 |
| 11 |
|
Serik Belediyespor | 21 | 9 | 2 | 10 | 28:30 | -2 | 29 |
| 12 |
|
Inegölspor | 21 | 8 | 3 | 10 | 24:29 | -5 | 27 |
| 13 |
|
Diyarbekirspor | 21 | 7 | 4 | 10 | 24:25 | -1 | 25 |
| 14 |
|
Etimesgut Belediyespor | 21 | 6 | 7 | 8 | 22:27 | -5 | 25 |
| 15 |
|
Turgutluspor | 21 | 5 | 8 | 8 | 20:32 | -12 | 23 |
| 16 |
|
Adıyamanspor | 21 | 7 | 1 | 13 | 29:38 | -9 | 22 |
| 17 |
|
Sarıyer SK | 21 | 5 | 3 | 13 | 22:34 | -12 | 18 |
| 18 |
|
Ergene Velimeşe | 21 | 5 | 3 | 13 | 22:42 | -20 | 18 |
| 19 |
|
Kahramanmaraşspor | 21 | 3 | 3 | 15 | 15:51 | -36 | 12 |
| 20 |
|
Niğde Anadolu FK | 21 | 1 | 4 | 16 | 13:50 | -37 | 7 |
| Ascenso | |
| Playoff | |
| Descenso |
