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| 27.02.2022 | 11:00 | Bayburt İl Özel İdare | - | Bodrum FK | 0:2 (0:0) | |
| 11:00 | Diyarbekirspor | - | Adıyamanspor | 0:0 (0:0) | ||
| 11:00 | Ergene Velimeşe | - | Niğde Anadolu FK | 1:3 (0:0) | ||
| 11:00 | Etimesgut Belediyespor | - | Afjet Afyonspor | 2:0 (0:0) | ||
| 11:00 | Sarıyer SK | - | Çorum FK | 1:1 (1:0) | ||
| 11:00 | Serik Belediyespor | - | Ankaraspor | 2:2 (0:2) | ||
| 11:00 | Sivas Belediyespor | - | Vanspor FK | 2:2 (0:1) | ||
| 11:00 | Turgutluspor | - | 1461 Trabzon FK | 1:0 (1:0) | ||
| 12:00 | Sakaryaspor | - | Inegölspor | 2:2 (1:2) | ||
| 28.02.2022 | 11:00 | Kahramanmaraşspor | - | Somaspor | 1:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sakaryaspor | 28 | 18 | 8 | 2 | 55:18 | 37 | 62 |
| 2 |
|
1461 Trabzon FK | 28 | 17 | 7 | 4 | 46:20 | 26 | 58 |
| 3 |
|
Bodrum FK | 28 | 16 | 5 | 7 | 43:22 | 21 | 53 |
| 4 |
|
Vanspor FK | 28 | 15 | 7 | 6 | 41:34 | 7 | 52 |
| 5 |
|
Sivas Belediyespor | 28 | 14 | 8 | 6 | 49:24 | 25 | 50 |
| 6 |
|
Afjet Afyonspor | 28 | 13 | 8 | 7 | 54:32 | 22 | 47 |
| 7 |
|
Bayburt İl Özel İdare | 28 | 14 | 5 | 9 | 37:28 | 9 | 47 |
| 8 |
|
Somaspor | 28 | 13 | 6 | 9 | 43:37 | 6 | 45 |
| 9 |
|
Çorum FK | 28 | 12 | 8 | 8 | 39:26 | 13 | 44 |
| 10 |
|
Inegölspor | 28 | 12 | 5 | 11 | 36:38 | -2 | 41 |
| 11 |
|
Ankaraspor | 28 | 10 | 10 | 8 | 44:32 | 12 | 40 |
| 12 |
|
Etimesgut Belediyespor | 28 | 9 | 9 | 10 | 35:39 | -4 | 36 |
| 13 |
|
Serik Belediyespor | 28 | 9 | 5 | 14 | 34:40 | -6 | 32 |
| 14 |
|
Sarıyer SK | 28 | 8 | 7 | 13 | 33:40 | -7 | 31 |
| 15 |
|
Diyarbekirspor | 28 | 8 | 5 | 15 | 27:33 | -6 | 29 |
| 16 |
|
Adıyamanspor | 28 | 9 | 2 | 17 | 36:53 | -17 | 29 |
| 17 |
|
Turgutluspor | 28 | 6 | 10 | 12 | 24:44 | -20 | 28 |
| 18 |
|
Ergene Velimeşe | 28 | 6 | 3 | 19 | 28:58 | -30 | 21 |
| 19 |
|
Kahramanmaraşspor | 28 | 4 | 5 | 19 | 20:63 | -43 | 17 |
| 20 |
|
Niğde Anadolu FK | 28 | 3 | 5 | 20 | 24:67 | -43 | 14 |
| Ascenso | |
| Playoff | |
| Descenso |
