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| 21.12.2021 | 15:00 | Antalyaspor | - | Kasımpaşa SK | 1:1 (1:0) | |
| 15:00 | İstanbul Başakşehir | - | Giresunspor | 3:1 (1:1) | ||
| 18:00 | Adana Demirspor | - | Galatasaray | 2:0 (0:0) | ||
| 18:00 | Altay Izmir | - | Trabzonspor | 1:2 (1:0) | ||
| 22.12.2021 | 15:00 | Hatayspor | - | Konyaspor | 1:3 (1:1) | |
| 15:00 | Sivasspor | - | Çaykur Rizespor | 1:1 (0:0) | ||
| 18:00 | Gaziantep FK | - | Alanyaspor | 2:1 (0:0) | ||
| 18:00 | Fatih Karagümrük | - | Fenerbahçe | 1:1 (1:1) | ||
| 23.12.2021 | 15:00 | Yeni Malatyaspor | - | Kayserispor | 2:2 (2:0) | |
| 18:00 | Beşiktaş | - | Göztepe | 2:1 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Trabzonspor | 18 | 14 | 3 | 1 | 36:14 | 22 | 45 |
| 2 |
|
Konyaspor | 18 | 10 | 6 | 2 | 31:15 | 16 | 36 |
| 3 |
|
İstanbul Başakşehir | 18 | 10 | 2 | 6 | 29:19 | 10 | 32 |
| 4 |
|
Fenerbahçe | 18 | 8 | 5 | 5 | 29:23 | 6 | 29 |
| 5 |
|
Adana Demirspor | 18 | 8 | 5 | 5 | 26:21 | 5 | 29 |
| 6 |
|
Hatayspor | 18 | 9 | 2 | 7 | 26:23 | 3 | 29 |
| 7 |
|
Beşiktaş | 18 | 8 | 4 | 6 | 30:27 | 3 | 28 |
| 8 |
|
Alanyaspor | 18 | 8 | 3 | 7 | 28:30 | -2 | 27 |
| 9 |
|
Sivasspor | 18 | 6 | 8 | 4 | 26:17 | 9 | 26 |
| 10 |
|
Fatih Karagümrük | 18 | 7 | 5 | 6 | 25:26 | -1 | 26 |
| 11 |
|
Gaziantep FK | 18 | 7 | 4 | 7 | 23:26 | -3 | 25 |
| 12 |
|
Galatasaray | 18 | 6 | 6 | 6 | 22:23 | -1 | 24 |
| 13 |
|
Giresunspor | 18 | 6 | 4 | 8 | 19:18 | 1 | 22 |
| 14 |
|
Antalyaspor | 18 | 6 | 4 | 8 | 21:25 | -4 | 22 |
| 15 |
|
Kayserispor | 18 | 5 | 6 | 7 | 24:28 | -4 | 21 |
| 16 |
|
Altay Izmir | 18 | 5 | 3 | 10 | 23:30 | -7 | 18 |
| 17 |
|
Çaykur Rizespor | 18 | 5 | 2 | 11 | 17:33 | -16 | 17 |
| 18 |
|
Yeni Malatyaspor | 18 | 4 | 3 | 11 | 16:32 | -16 | 15 |
| 19 |
|
Göztepe | 18 | 3 | 5 | 10 | 17:27 | -10 | 14 |
| 20 |
|
Kasımpaşa SK | 18 | 2 | 6 | 10 | 17:28 | -11 | 12 |
| Champions League | |
| CL Ronda previa | |
| ECL Ronda previa | |
| Descenso |
