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| 22.01.2022 | 11:30 | Yeni Malatyaspor | - | Beşiktaş | 1:1 (0:0) | |
| 14:00 | Adana Demirspor | - | Fatih Karagümrük | 5:0 (1:0) | ||
| 14:00 | Sivasspor | - | Fenerbahçe | 1:1 (0:1) | ||
| 17:00 | İstanbul Başakşehir | - | Göztepe | 1:2 (0:1) | ||
| 23.01.2022 | 11:30 | Hatayspor | - | Çaykur Rizespor | 0:0 (0:0) | |
| 11:30 | Kasımpaşa SK | - | Kayserispor | 3:1 (2:1) | ||
| 14:00 | Altay Izmir | - | Konyaspor | 0:1 (0:0) | ||
| 14:00 | Antalyaspor | - | Gaziantep FK | 0:0 (0:0) | ||
| 14:00 | Giresunspor | - | Alanyaspor | 1:3 (1:2) | ||
| 17:00 | Galatasaray | - | Trabzonspor | 1:2 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Trabzonspor | 23 | 16 | 6 | 1 | 41:17 | 24 | 54 |
| 2 |
|
Konyaspor | 23 | 13 | 6 | 4 | 35:18 | 17 | 45 |
| 3 |
|
Alanyaspor | 23 | 11 | 5 | 7 | 41:33 | 8 | 38 |
| 4 |
|
Adana Demirspor | 23 | 10 | 7 | 6 | 35:25 | 10 | 37 |
| 5 |
|
İstanbul Başakşehir | 23 | 11 | 4 | 8 | 33:24 | 9 | 37 |
| 6 |
|
Fenerbahçe | 23 | 10 | 7 | 6 | 36:28 | 8 | 37 |
| 7 |
|
Beşiktaş | 23 | 10 | 6 | 7 | 35:31 | 4 | 36 |
| 8 |
|
Hatayspor | 23 | 11 | 3 | 9 | 32:34 | -2 | 36 |
| 9 |
|
Gaziantep FK | 23 | 9 | 6 | 8 | 27:28 | -1 | 33 |
| 10 |
|
Sivasspor | 23 | 7 | 10 | 6 | 30:24 | 6 | 31 |
| 11 |
|
Kayserispor | 23 | 8 | 7 | 8 | 31:32 | -1 | 31 |
| 12 |
|
Fatih Karagümrük | 23 | 8 | 6 | 9 | 29:36 | -7 | 30 |
| 13 |
|
Kasımpaşa SK | 23 | 7 | 6 | 10 | 30:31 | -1 | 27 |
| 14 |
|
Göztepe | 23 | 7 | 6 | 10 | 28:31 | -3 | 27 |
| 15 |
|
Galatasaray | 23 | 7 | 6 | 10 | 28:33 | -5 | 27 |
| 16 |
|
Giresunspor | 23 | 7 | 5 | 11 | 22:25 | -3 | 26 |
| 17 |
|
Antalyaspor | 23 | 6 | 6 | 11 | 23:34 | -11 | 24 |
| 18 |
|
Çaykur Rizespor | 23 | 6 | 4 | 13 | 21:39 | -18 | 22 |
| 19 |
|
Altay Izmir | 23 | 5 | 3 | 15 | 24:38 | -14 | 18 |
| 20 |
|
Yeni Malatyaspor | 23 | 4 | 5 | 14 | 18:38 | -20 | 17 |
| Champions League | |
| CL Ronda previa | |
| ECL Ronda previa | |
| Descenso |
