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| 11.09.2021 | 16:00 | Fatih Karagümrük | - | Adana Demirspor | 4:0 (2:0) | |
| 16:00 | Konyaspor | - | Altay Izmir | 3:1 (2:0) | ||
| 19:00 | Beşiktaş | - | Yeni Malatyaspor | 3:0 (2:0) | ||
| 19:00 | Kayserispor | - | Kasımpaşa SK | 2:0 (1:0) | ||
| 12.09.2021 | 16:00 | Çaykur Rizespor | - | Hatayspor | 0:2 (0:0) | |
| 16:00 | Fenerbahçe | - | Sivasspor | 1:1 (1:1) | ||
| 19:00 | Göztepe | - | İstanbul Başakşehir | 2:1 (0:1) | ||
| 19:00 | Trabzonspor | - | Galatasaray | 2:2 (1:2) | ||
| 13.09.2021 | 19:00 | Alanyaspor | - | Giresunspor | 1:0 (1:0) | |
| 19:00 | Gaziantep FK | - | Antalyaspor | 2:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Beşiktaş | 4 | 3 | 1 | 0 | 7:0 | 7 | 10 |
| 2 |
|
Trabzonspor | 4 | 3 | 1 | 0 | 10:4 | 6 | 10 |
| 3 |
|
Fenerbahçe | 4 | 3 | 1 | 0 | 6:1 | 5 | 10 |
| 4 |
|
Konyaspor | 4 | 3 | 1 | 0 | 7:3 | 4 | 10 |
| 5 |
|
Galatasaray | 4 | 2 | 2 | 0 | 8:5 | 3 | 8 |
| 6 |
|
Hatayspor | 4 | 2 | 1 | 1 | 9:3 | 6 | 7 |
| 7 |
|
Fatih Karagümrük | 4 | 2 | 1 | 1 | 7:3 | 4 | 7 |
| 8 |
|
Kayserispor | 4 | 2 | 1 | 1 | 4:4 | 0 | 7 |
| 9 |
|
Altay Izmir | 4 | 2 | 0 | 2 | 8:6 | 2 | 6 |
| 10 |
|
Yeni Malatyaspor | 4 | 2 | 0 | 2 | 4:8 | -4 | 6 |
| 11 |
|
Alanyaspor | 4 | 2 | 0 | 2 | 3:9 | -6 | 6 |
| 12 |
|
Göztepe | 4 | 1 | 2 | 1 | 5:5 | 0 | 5 |
|
Kasımpaşa SK | 4 | 1 | 2 | 1 | 5:5 | 0 | 5 | |
| 14 |
|
Gaziantep FK | 4 | 1 | 1 | 2 | 4:5 | -1 | 4 |
| 15 |
|
Antalyaspor | 4 | 1 | 1 | 2 | 4:7 | -3 | 4 |
| 16 |
|
Sivasspor | 4 | 0 | 2 | 2 | 4:6 | -2 | 2 |
| 17 |
|
Adana Demirspor | 4 | 0 | 2 | 2 | 2:7 | -5 | 2 |
| 18 |
|
Çaykur Rizespor | 4 | 0 | 1 | 3 | 2:8 | -6 | 1 |
| 19 |
|
İstanbul Başakşehir | 4 | 0 | 0 | 4 | 2:6 | -4 | 0 |
| 20 |
|
Giresunspor | 4 | 0 | 0 | 4 | 0:6 | -6 | 0 |
| Champions League | |
| CL Ronda previa | |
| ECL Ronda previa | |
| Descenso |
