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| 19.09.2021 | 13:00 | Andijon PFK | - | Pakhtakor Tashkent | 1:0 (1:0) | |
| 15:30 | Metallurg Bekobod | - | FK Qo’qon 1912 | 0:1 (0:0) | ||
| 20.09.2021 | 16:00 | Qizilqum Zarafshon | - | FC AGMK | 0:0 (0:0) | |
| 16:00 | FK Turon | - | Navbahor Namangan | 0:1 (0:1) | ||
| 21.09.2021 | 13:30 | FK Mash'al Muborak | - | So’g’diyona PFK | 0:0 (0:0) | |
| 16:00 | Bunyodkor PFK | - | Lokomotiv Tashkent | 3:2 (1:1) | ||
| 11.11.2021 | 11:00 | Surkhon Termez FK | - | FC Nasaf | 2:2 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pakhtakor Tashkent | 19 | 15 | 3 | 1 | 32:7 | 25 | 48 |
| 2 |
|
So’g’diyona PFK | 19 | 9 | 8 | 2 | 22:12 | 10 | 35 |
| 3 |
|
FC AGMK | 19 | 9 | 6 | 4 | 23:17 | 6 | 33 |
| 4 |
|
Bunyodkor PFK | 19 | 9 | 5 | 5 | 31:18 | 13 | 32 |
| 5 |
|
FC Nasaf | 19 | 9 | 4 | 6 | 29:18 | 11 | 31 |
| 6 |
|
Navbahor Namangan | 19 | 7 | 7 | 5 | 16:13 | 3 | 28 |
| 7 |
|
Qizilqum Zarafshon | 19 | 6 | 9 | 4 | 20:17 | 3 | 27 |
| 8 |
|
Lokomotiv Tashkent | 19 | 7 | 5 | 7 | 26:22 | 4 | 26 |
| 9 |
|
FK Qo’qon 1912 | 19 | 6 | 6 | 7 | 23:24 | -1 | 24 |
| 10 |
|
Metallurg Bekobod | 19 | 6 | 1 | 12 | 17:27 | -10 | 19 |
| 11 |
|
FK Mash'al Muborak | 19 | 4 | 6 | 9 | 16:27 | -11 | 18 |
| 12 |
|
Andijon PFK | 19 | 4 | 3 | 12 | 15:31 | -16 | 15 |
| 13 |
|
Surkhon Termez FK | 19 | 4 | 3 | 12 | 12:33 | -21 | 15 |
| 14 |
|
FK Turon | 19 | 2 | 6 | 11 | 11:27 | -16 | 12 |
| Champions League | |
| CL Ronda previa | |
| Permanencia | |
| Descenso |
