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| Div. Prof. | 12.03.2021 | Real Tomayapo | - | Always Ready | 1:0 | ??? |
| Div. Prof. | 02.04.2021 | Real Tomayapo | - | Real Potosí | 0:0 | ??? |
| Div. Prof. | 25.04.2021 | Real Tomayapo | - | Blooming | 2:1 | ??? |
| Div. Prof. | 11.05.2021 | Real Tomayapo | - | Club Aurora | 1:2 | ??? |
| Div. Prof. | 10.07.2021 | Real Tomayapo | - | Independiente Petrolero | 0:2 | ??? |
| Div. Prof. | 21.07.2021 | Real Tomayapo | - | Real Santa Cruz | 2:1 | ??? |
| Div. Prof. | 01.08.2021 | Real Tomayapo | - | Oriente Petrolero | 0:1 | ??? |
| Div. Prof. | 08.08.2021 | Real Tomayapo | - | Jorge Wilstermann | 1:2 | ??? |
| Div. Prof. | 22.08.2021 | Real Tomayapo | - | Royal Pari | 1:4 | ??? |
| Div. Prof. | 18.09.2021 | Real Tomayapo | - | CD Guabirá | 1:1 | ??? |
| Div. Prof. | 26.09.2021 | Real Tomayapo | - | Bolívar | 1:3 | ??? |
| Div. Prof. | 28.10.2021 | Real Tomayapo | - | Club San José | 1:0 | ??? |
| Div. Prof. | 23.11.2021 | Real Tomayapo | - | Nacional Potosí | 3:0 | ??? |
| Div. Prof. | 03.12.2021 | Real Tomayapo | - | The Strongest | 0:0 | ??? |
| Div. Prof. | 11.12.2021 | Real Tomayapo | - | Atlético Palmaflor | 3:3 | ??? |
Bolivia